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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p83 MR0 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2p83 MR0Beta-secretase 1 3.4.23.46 1.270
2iqg F2IBeta-secretase 1 3.4.23.46 1.057
3lpi Z74Beta-secretase 1 3.4.23.46 1.000
3cid 318Beta-secretase 1 3.4.23.46 0.973
3lpk Z76Beta-secretase 1 3.4.23.46 0.965
3nsh 957Beta-secretase 1 3.4.23.46 0.944
4i0i 957Beta-secretase 1 3.4.23.46 0.944
3cic 316Beta-secretase 1 3.4.23.46 0.942
3lpj Z75Beta-secretase 1 3.4.23.46 0.938
3cib 314Beta-secretase 1 3.4.23.46 0.906
2hm1 LIQBeta-secretase 1 3.4.23.46 0.904
2viz VG4Beta-secretase 1 3.4.23.46 0.896
2xfi XFIBeta-secretase 1 3.4.23.46 0.896
2vj6 VG5Beta-secretase 1 3.4.23.46 0.892
2vj7 VG6Beta-secretase 1 3.4.23.46 0.889
3qi1 C6ABeta-secretase 1 3.4.23.46 0.882
2vij C44Beta-secretase 1 3.4.23.46 0.880
2hiz LIJBeta-secretase 1 3.4.23.46 0.875
3r2f PB0Beta-secretase 1 3.4.23.46 0.870
2vnn CM7Beta-secretase 1 3.4.23.46 0.868
2xfj VG5Beta-secretase 1 3.4.23.46 0.867
2xfk AA9Beta-secretase 1 3.4.23.46 0.867
2vie VG0Beta-secretase 1 3.4.23.46 0.865
3veu 0GOBeta-secretase 1 3.4.23.46 0.858
3k5c 0BIBeta-secretase 1 3.4.23.46 0.857
3k5g BJCBeta-secretase 1 3.4.23.46 0.855
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.847
2b8v 3BNBeta-secretase 1 3.4.23.46 0.839
2vnm CM8Beta-secretase 1 3.4.23.46 0.838
2viy VG3Beta-secretase 1 3.4.23.46 0.828
4ke0 1R8Beta-secretase 1 3.4.23.46 0.828
4dpf 0LGBeta-secretase 1 3.4.23.46 0.825
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.824
3ohf 3HFBeta-secretase 1 3.4.23.46 0.821
4ke1 1R6Beta-secretase 1 3.4.23.46 0.820
1w51 L01Beta-secretase 1 3.4.23.46 0.810
3i25 MV7Beta-secretase 1 3.4.23.46 0.809
3dv5 BAVBeta-secretase 1 3.4.23.46 0.808
4k8s 1QTBeta-secretase 1 3.4.23.46 0.805
4fco 0U4Beta-secretase 1 3.4.23.46 0.803
3ohh 3HHBeta-secretase 1 3.4.23.46 0.802
3k5f AYHBeta-secretase 1 3.4.23.46 0.801
2fdp FRPBeta-secretase 1 3.4.23.46 0.797
4lxa 1YSBeta-secretase 1 3.4.23.46 0.797
2b8l 5HABeta-secretase 1 3.4.23.46 0.793
4k9h 1QUBeta-secretase 1 3.4.23.46 0.792
2wez ZYEBeta-secretase 1 3.4.23.46 0.788
4lxk 1YTBeta-secretase 1 3.4.23.46 0.785
4ewo 996Beta-secretase 1 3.4.23.46 0.781
4gid 0GHBeta-secretase 1 3.4.23.46 0.779
2p8h MY9Beta-secretase 1 3.4.23.46 0.776
3skg PB8Beta-secretase 1 3.4.23.46 0.766
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.763
4lxm 1YUBeta-secretase 1 3.4.23.46 0.760
4dpi 0N1Beta-secretase 1 3.4.23.46 0.756
2qzl IXSBeta-secretase 1 3.4.23.46 0.750
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.750
2f3e AXQBeta-secretase 1 3.4.23.46 0.740
3ixj 586Beta-secretase 1 3.4.23.46 0.735
3qbh QBHBeta-secretase 1 3.4.23.46 0.734
2vj9 VG7Beta-secretase 1 3.4.23.46 0.733
2p4j 23IBeta-secretase 1 3.4.23.46 0.729
4d89 BXDBeta-secretase 1 3.4.23.46 0.720
3vf3 0GSBeta-secretase 1 3.4.23.46 0.719
1e80 0GQEndothiapepsin 3.4.23.22 0.717
1od1 0QSEndothiapepsin 3.4.23.22 0.716
2vkm BSDBeta-secretase 1 3.4.23.46 0.715
1gvv 0GMEndothiapepsin 3.4.23.22 0.706
3own 3OXRenin 3.4.23.15 0.690
3dm6 757Beta-secretase 1 3.4.23.46 0.680
2jji 0QSEndothiapepsin 3.4.23.22 0.673
2ntr L00Beta-secretase 1 3.4.23.46 0.667
3tpr 5HABeta-secretase 1 3.4.23.46 0.667
2avm 2NCGag-Pol polyprotein 3.4.23.16 0.661
2oah QINBeta-secretase 1 3.4.23.46 0.659
3ixk 929Beta-secretase 1 3.4.23.46 0.658
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.654