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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2nry STU Interleukin-1 receptor-associated kinase 4 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 1.023
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.866
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.832
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.829
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.828
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.819
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.810
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.802
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.802
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.800
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.800
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.795
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.789
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.787
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.782
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.780
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.779
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.776
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.776
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.768
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.764
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.761
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.758
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.756
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.749
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.749
4e5i 0N9Polymerase acidic protein / 0.744
1byg STUTyrosine-protein kinase CSK / 0.741
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.735
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.733
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.724
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.722
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.721
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.717
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.716
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.713
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.699
4twp AXITyrosine-protein kinase ABL1 2.7.10.2 0.691
3biz 61EWee1-like protein kinase 2.7.10.2 0.683
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.681
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.681
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.667
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3qzh X69Cyclin-dependent kinase 2 2.7.11.22 0.659
1xjd STUProtein kinase C theta type 2.7.11.13 0.654
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.651