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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ivu ZD6 Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 1.116
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.837
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.763
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.760
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.750
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.738
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.707
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.698
4qmx H8HSerine/threonine-protein kinase 24 2.7.11.1 0.692
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.691
2xir 00JVascular endothelial growth factor receptor 2 2.7.10.1 0.676
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.674
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.674
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.667
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.659
3uvp 048Mitogen-activated protein kinase 14 / 0.655
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.653