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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itz IRE Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2itz IREEpidermal growth factor receptor 2.7.10.1 1.155
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.911
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.831
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.787
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.784
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.764
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.758
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.675
2wot ZZGTGF-beta receptor type-1 2.7.11.30 0.670
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.670
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.666
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.663
3w2s W2REpidermal growth factor receptor 2.7.10.1 0.663
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.660
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.654
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.654
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.651