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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gdo 12C Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 1.160
4e5i 0N9Polymerase acidic protein / 0.744
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.731
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.722
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.712
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.685
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.684
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4afj SJJGlycogen synthase kinase-3 beta 2.7.11.26 0.676
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.669
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.667
3vs2 VSBTyrosine-protein kinase HCK 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.659
2q8i RDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2 0.658
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3w16 P9JAurora kinase A 2.7.11.1 0.657
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2yne YNEGlycylpeptide N-tetradecanoyltransferase / 0.654
4g1w G1WMitogen-activated protein kinase 8 2.7.11.24 0.654
3qzi X72Cyclin-dependent kinase 2 2.7.11.22 0.652
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2obj VRVSerine/threonine-protein kinase pim-1 2.7.11.1 0.651
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651