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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gcd STU Serine/threonine-protein kinase TAO2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 1.036
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.837
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.833
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.823
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.821
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.802
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.800
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.797
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.797
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.793
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.784
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.783
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.783
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.783
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.774
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.771
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.771
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.765
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.759
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.758
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.752
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.751
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.749
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.737
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.736
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.735
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.731
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.728
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.726
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.725
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.723
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.722
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.720
3zew STUEphrin type-B receptor 4 2.7.10.1 0.719
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.718
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.718
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.711
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.704
1xjd STUProtein kinase C theta type 2.7.11.13 0.702
1byg STUTyrosine-protein kinase CSK / 0.689
3cqe P91Wee1-like protein kinase 2.7.10.2 0.685
3d7t STUTyrosine-protein kinase CSK / 0.682
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.680
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.677
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.673
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.669
3cr0 809Wee1-like protein kinase 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.650