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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g8d UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g8d UMPThymidylate synthase / 0.988
2g86 UMPThymidylate synthase / 0.916
2g8a UMPThymidylate synthase / 0.866
1tsv UMPThymidylate synthase / 0.815
1tsy UMPThymidylate synthase / 0.794
2tdm UMPThymidylate synthase / 0.793
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.775
1tsx UMPThymidylate synthase / 0.760
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.745
5by6 UMPThymidylate synthase / 0.741
4dq1 UMPThymidylate synthase / 0.739
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.738
1bp0 UMPThymidylate synthase / 0.736
1tys TMPThymidylate synthase / 0.735
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.731
1vzb UMPThymidylate synthase / 0.729
1bp6 UMPThymidylate synthase / 0.722
1njd UMPThymidylate synthase / 0.716
1f28 UMPThymidylate synthase 2.1.1.45 0.715
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.711
4fox UMPThymidylate synthase ThyA / 0.710
3bgx TMPThymidylate synthase / 0.709
4ein NOHThymidylate synthase 2.1.1.45 0.705
2vet UMPThymidylate synthase / 0.703
2g89 UMPThymidylate synthase / 0.700
3qj7 UMPThymidylate synthase ThyA / 0.698
1vza UMPThymidylate synthase / 0.692
4xsd UMPThymidylate synthase 2.1.1.45 0.688
4yal 2AMNADPH--cytochrome P450 reductase / 0.688
1njc DCMThymidylate synthase / 0.687
1bid UMPThymidylate synthase / 0.685
1nja DCMThymidylate synthase / 0.682
4e5o UMPThymidylate synthase 2.1.1.45 0.680
1nje DCMThymidylate synthase / 0.668
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.665
3mje NDPAmphB / 0.663
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.662
2fto TMPThymidylate synthase / 0.659
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.658
1djl NAPNAD(P) transhydrogenase, mitochondrial 1.6.1.2 0.654
1jmg UMPThymidylate synthase / 0.654
1njb UMPThymidylate synthase / 0.652
4irr UMPThymidylate synthase / 0.651
1bpj UMPThymidylate synthase / 0.650