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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g8a UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g8a UMPThymidylate synthase / 0.994
2g8d UMPThymidylate synthase / 0.866
2g86 UMPThymidylate synthase / 0.854
2tdm UMPThymidylate synthase / 0.835
2g89 UMPThymidylate synthase / 0.820
1tsv UMPThymidylate synthase / 0.817
1bid UMPThymidylate synthase / 0.812
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.802
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.799
1bp0 UMPThymidylate synthase / 0.796
4dq1 UMPThymidylate synthase / 0.795
1f28 UMPThymidylate synthase 2.1.1.45 0.792
2fto TMPThymidylate synthase / 0.792
1tsy UMPThymidylate synthase / 0.790
1nja DCMThymidylate synthase / 0.788
2vet UMPThymidylate synthase / 0.776
3bgx TMPThymidylate synthase / 0.775
4e5o UMPThymidylate synthase 2.1.1.45 0.775
4isk UMPThymidylate synthase / 0.773
1tsx UMPThymidylate synthase / 0.771
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.770
1tys TMPThymidylate synthase / 0.768
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.768
5by6 UMPThymidylate synthase / 0.763
1bp6 UMPThymidylate synthase / 0.750
1vzb UMPThymidylate synthase / 0.749
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.747
4ein NOHThymidylate synthase 2.1.1.45 0.738
3qj7 UMPThymidylate synthase ThyA / 0.727
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.726
4fox UMPThymidylate synthase ThyA / 0.726
4eb4 UMPThymidylate synthase 2.1.1.45 0.725
4irr UMPThymidylate synthase / 0.724
1njc DCMThymidylate synthase / 0.717
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.708
1jmh UMPThymidylate synthase / 0.706
1nje DCMThymidylate synthase / 0.706
1njd UMPThymidylate synthase / 0.704
4h0u UMPThymidylate synthase / 0.703
2tsr UMPThymidylate synthase 2.1.1.45 0.691
1thy UMPThymidylate synthase / 0.690
1ddu DDUThymidylate synthase / 0.685
1vza UMPThymidylate synthase / 0.680
1tdc UMPThymidylate synthase / 0.676
1jmf UMPThymidylate synthase / 0.674
4iqq UMPThymidylate synthase / 0.674
4gs4 ACOAlpha-tubulin N-acetyltransferase 1 / 0.673
3hb8 UMPThymidylate synthase 2.1.1.45 0.671
1njb UMPThymidylate synthase / 0.664
1aob DDUThymidylate synthase / 0.663
4xsd UMPThymidylate synthase 2.1.1.45 0.655
1bpj UMPThymidylate synthase / 0.653
1x1b SAHC-20 methyltransferase / 0.652