Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g25 TDK Pyruvate dehydrogenase E1 component 1.2.4.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 1.423
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 1.183
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 1.073
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 1.009
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.974
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.946
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.897
3ahi HTLProbable phosphoketolase / 0.876
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.870
3ahj TPPProbable phosphoketolase / 0.834
3ahe THDProbable phosphoketolase / 0.820
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.815
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.795
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.794
3upt TPPTransketolase / 0.784
1tkc M6TTransketolase 1 2.2.1.1 0.783
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.781
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.781
2r8o T5XTransketolase 1 / 0.769
1tkb N1TTransketolase 1 2.2.1.1 0.768
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.768
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.766
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.765
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.762
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.762
2ag0 TPPBenzaldehyde lyase / 0.757
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.757
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.753
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.752
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.752
2r8p T6FTransketolase 1 / 0.751
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.747
1trk TPPTransketolase 1 2.2.1.1 0.745
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.744
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.743
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.743
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.740
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.740
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.740
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.739
3m7i TPPTransketolase / 0.739
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.738
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.737
1ay0 TPPTransketolase 1 2.2.1.1 0.736
1ngs TPPTransketolase 1 2.2.1.1 0.736
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.735
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.729
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.728
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.728
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.728
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.728
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.724
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.724
3m34 TPPTransketolase / 0.724
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.723
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.723
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.722
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.722
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.721
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.721
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.720
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.720
2ez9 TDKPyruvate oxidase 1.2.3.3 0.717
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.717
3d7k D7KBenzaldehyde lyase / 0.716
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.713
4yj2 GTPTubulin alpha-1B chain / 0.713
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.709
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.707
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.706
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.705
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.705
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.704
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.704
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.704
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.702
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.702
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.702
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.698
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.697
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.695
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.694
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.693
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.691
5ahk TPPAcetolactate synthase II, large subunit / 0.690
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.690
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.687
4cok TPPPyruvate decarboxylase / 0.687
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.687
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.687
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.685
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.685
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.685
2r5n TPPTransketolase 1 / 0.683
1kek HTLPyruvate synthase / 0.682
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.680
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.677
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.677
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.676
2c42 TPPPyruvate synthase / 0.676
3n0z 3ATAdenylate cyclase 2 / 0.674
2c3p 1TPPyruvate synthase / 0.673
2uz1 TPPBenzaldehyde lyase / 0.672
3iae D7KBenzaldehyde lyase / 0.670
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.668
3rim TPPTransketolase 2.2.1.1 0.668
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.668
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.667
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.667
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.667
1y9d TPPPyruvate oxidase 1.2.3.3 0.664
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.664
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.661
2ezt TDMPyruvate oxidase 1.2.3.3 0.659
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.659
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.658
2pan TDPGlyoxylate carboligase 4.1.1.47 0.656
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.653
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.651
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.651
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.651
3hqd ANPKinesin-like protein KIF11 / 0.650