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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fto TMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fto TMPThymidylate synthase / 1.097
1tys TMPThymidylate synthase / 1.050
3bgx TMPThymidylate synthase / 0.991
5by6 UMPThymidylate synthase / 0.950
4e5o UMPThymidylate synthase 2.1.1.45 0.947
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.944
3qj7 UMPThymidylate synthase ThyA / 0.925
4fox UMPThymidylate synthase ThyA / 0.924
4dq1 UMPThymidylate synthase / 0.922
1f28 UMPThymidylate synthase 2.1.1.45 0.914
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.912
4ein NOHThymidylate synthase 2.1.1.45 0.897
4irr UMPThymidylate synthase / 0.877
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.862
2vet UMPThymidylate synthase / 0.855
4eb4 UMPThymidylate synthase 2.1.1.45 0.854
4isk UMPThymidylate synthase / 0.852
4h0u UMPThymidylate synthase / 0.848
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.833
2g86 UMPThymidylate synthase / 0.817
2tdm UMPThymidylate synthase / 0.808
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.807
1vza UMPThymidylate synthase / 0.806
2g8a UMPThymidylate synthase / 0.792
1bid UMPThymidylate synthase / 0.791
1jmf UMPThymidylate synthase / 0.787
4iqq UMPThymidylate synthase / 0.771
1bp0 UMPThymidylate synthase / 0.764
1nja DCMThymidylate synthase / 0.764
1vzb UMPThymidylate synthase / 0.749
1tsv UMPThymidylate synthase / 0.745
1tdu DURThymidylate synthase / 0.742
4psg NOHThymidylate synthase / 0.742
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.737
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.733
2tsr UMPThymidylate synthase 2.1.1.45 0.731
1tsx UMPThymidylate synthase / 0.728
2g89 UMPThymidylate synthase / 0.727
1jmg UMPThymidylate synthase / 0.726
1tsy UMPThymidylate synthase / 0.725
1njc DCMThymidylate synthase / 0.722
1ddu DDUThymidylate synthase / 0.708
1njd UMPThymidylate synthase / 0.685
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.685
1tdc UMPThymidylate synthase / 0.681
1bp6 UMPThymidylate synthase / 0.679
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.678
1bdu DURThymidylate synthase / 0.677
1jmi UMPThymidylate synthase / 0.667
1aob DDUThymidylate synthase / 0.664
1f06 NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.663
1mb4 NDPAspartate-semialdehyde dehydrogenase 1 / 0.661
2g8d UMPThymidylate synthase / 0.659
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.656
1njb UMPThymidylate synthase / 0.654
4luh DIUSerum albumin / 0.654