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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e37 NAD L-lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e37 NADL-lactate dehydrogenase / 0.958
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.715
3m2t NADProbable dehydrogenase / 0.680
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.679
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.674
5lc1 NADL-threonine 3-dehydrogenase / 0.674
4j49 NADUncharacterized protein / 0.673
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.672
4j43 NADUncharacterized protein / 0.671
4j49 NAIUncharacterized protein / 0.671
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.670
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.668
3wsw NADL-lactate dehydrogenase / 0.668
1uxj NADMalate dehydrogenase / 0.666
1npd NADQuinate/shikimate dehydrogenase / 0.665
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.665
3ggp NADPrephenate dehydrogenase / 0.664
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.664
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.663
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.663
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.663
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.662
1ib6 NADMalate dehydrogenase / 0.660
4jk3 NADUncharacterized protein / 0.660
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.658
5jla NADPutative short-chain dehydrogenase/reductase / 0.657
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.656
4j4b NAIUncharacterized protein / 0.656
1pzh NADLactate dehydrogenase / 0.654
1sow NADL-lactate dehydrogenase 1.1.1.27 0.653
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.653
2g5c NADPrephenate dehydrogenase / 0.653
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.653
4yag NAIC alpha-dehydrogenase / 0.653
4yai NAIC alpha-dehydrogenase / 0.653
3mje NDPAmphB / 0.652
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.650