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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2drc MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2drc MTXDihydrofolate reductase 1.5.1.3 1.083
4dfr MTXDihydrofolate reductase 1.5.1.3 1.046
3drc MTXDihydrofolate reductase 1.5.1.3 1.037
1dra MTXDihydrofolate reductase 1.5.1.3 1.017
5hi6 MTXDihydrofolate reductase / 1.003
3och 2MXDihydrofolate reductase 1.5.1.3 0.996
3ia4 MTXDihydrofolate reductase / 0.965
1dhj MTXDihydrofolate reductase 1.5.1.3 0.962
3dau MTXDihydrofolate reductase 1.5.1.3 0.931
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.916
1tdr MTXDihydrofolate reductase 1.5.1.3 0.915
1df7 MTXDihydrofolate reductase 1.5.1.3 0.903
4p66 MTXDihydrofolate reductase / 0.897
1dhi MTXDihydrofolate reductase 1.5.1.3 0.885
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.882
1dls MTXDihydrofolate reductase 1.5.1.3 0.869
3tq9 MTXDihydrofolate reductase / 0.868
2zza FOLDihydrofolate reductase / 0.850
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.849
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.846
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.845
1dre MTXDihydrofolate reductase 1.5.1.3 0.831
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.828
1drb MTXDihydrofolate reductase 1.5.1.3 0.823
2qk8 MTXDihydrofolate reductase / 0.814
3eig MTXDihydrofolate reductase 1.5.1.3 0.810
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.808
3dfr MTXDihydrofolate reductase 1.5.1.3 0.803
1jol FFODihydrofolate reductase 1.5.1.3 0.802
1u70 MTXDihydrofolate reductase 1.5.1.3 0.799
1dyj DDFDihydrofolate reductase 1.5.1.3 0.794
4qi9 MTXDihydrofolate reductase / 0.784
4x5g FOLDihydrofolate reductase 1.5.1.3 0.775
1dds MTXDihydrofolate reductase 1.5.1.3 0.774
4x5f FOLDihydrofolate reductase 1.5.1.3 0.770
1hfr MOTDihydrofolate reductase 1.5.1.3 0.769
1e26 GPBDihydrofolate reductase 1.5.1.3 0.766
1ohj COPDihydrofolate reductase 1.5.1.3 0.762
3dat MTXDihydrofolate reductase / 0.762
1hfp MOTDihydrofolate reductase 1.5.1.3 0.759
1u72 MTXDihydrofolate reductase 1.5.1.3 0.758
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.755
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.753
1ddr MTXDihydrofolate reductase 1.5.1.3 0.752
4x5h FOLDihydrofolate reductase 1.5.1.3 0.749
1hfq MOTDihydrofolate reductase 1.5.1.3 0.748
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.748
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.745
1jom FFODihydrofolate reductase 1.5.1.3 0.743
1dyh DZFDihydrofolate reductase 1.5.1.3 0.742
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.741
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.740
5ccc DDFDihydrofolate reductase 1.5.1.3 0.740
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.739
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.737
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.736
2dhf DZFDihydrofolate reductase 1.5.1.3 0.732
3frd DHFDihydrofolate reductase 1.5.1.3 0.731
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.729
3ghv GHCDihydrofolate reductase 1.5.1.3 0.726
4p68 MTXDihydrofolate reductase / 0.726
4i13 FOLDihydrofolate reductase 1.5.1.3 0.724
4x5i FOLDihydrofolate reductase 1.5.1.3 0.724
4m6k FOLDihydrofolate reductase 1.5.1.3 0.720
1drf FOLDihydrofolate reductase 1.5.1.3 0.719
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.718
4fhb FOLDihydrofolate reductase 1.5.1.3 0.717
2w3m FOLDihydrofolate reductase 1.5.1.3 0.714
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.714
1dyi FOLDihydrofolate reductase 1.5.1.3 0.712
1dhf FOLDihydrofolate reductase 1.5.1.3 0.711
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.704
4i1n FOLDihydrofolate reductase 1.5.1.3 0.703
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.701
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.701
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.694
2d0k FOLDihydrofolate reductase 1.5.1.3 0.694
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.693
4m6l 21VDihydrofolate reductase 1.5.1.3 0.692
7dfr FOLDihydrofolate reductase 1.5.1.3 0.692
3tqb FOLDihydrofolate reductase / 0.691
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.688
1daj MOTDihydrofolate reductase 1.5.1.3 0.686
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.686
4kfj FOLDihydrofolate reductase 1.5.1.3 0.680
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.672
4kjj FOLDihydrofolate reductase 1.5.1.3 0.670
4elb 34SDihydrofolate reductase / 0.669
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.667
1s3u TQDDihydrofolate reductase 1.5.1.3 0.661
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.657
1ohk COPDihydrofolate reductase 1.5.1.3 0.656
1s3v TQDDihydrofolate reductase 1.5.1.3 0.656
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.653
3ghw GHWDihydrofolate reductase 1.5.1.3 0.653
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.653
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.653
4ele 31IDihydrofolate reductase / 0.652
4to1 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.652