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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dq7 STU Tyrosine-protein kinase Fyn 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 1.095
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.939
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.930
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.902
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.887
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.866
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.864
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.863
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.852
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.850
1xjd STUProtein kinase C theta type 2.7.11.13 0.848
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.848
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.835
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.834
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.822
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.812
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.810
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.808
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.805
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.802
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.801
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.796
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.790
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.786
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.783
3zew STUEphrin type-B receptor 4 2.7.10.1 0.779
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.775
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.766
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.764
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.764
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.750
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.744
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.744
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.743
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.727
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.712
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.703
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.703
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.700
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.698
2z2w 770Wee1-like protein kinase 2.7.10.2 0.678
4mcv 29KProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.678
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.667
3bi6 396Wee1-like protein kinase 2.7.10.2 0.661
1byg STUTyrosine-protein kinase CSK / 0.656
2piu DHTAndrogen receptor / 0.651