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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2buj STU Serine/threonine-protein kinase 16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2buj STUSerine/threonine-protein kinase 16 / 0.967
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.763
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.705
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.699
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.693
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.682
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.680
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.674
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.661
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.657
2z2w 770Wee1-like protein kinase 2.7.10.2 0.650