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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bmc MPY Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bmc MPYAurora kinase A 2.7.11.1 0.861
2j50 627Aurora kinase A 2.7.11.1 0.693
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.690
3w10 RO9Aurora kinase A 2.7.11.1 0.683
4qo9 627Serine/threonine-protein kinase 24 2.7.11.1 0.675
2j4z 626Aurora kinase A 2.7.11.1 0.674
2c4g 514Cyclin-dependent kinase 2 2.7.11.22 0.671
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.670
3w16 P9JAurora kinase A 2.7.11.1 0.670
2xba 571ALK tyrosine kinase receptor 2.7.10.1 0.669
4f63 0S7Fibroblast growth factor receptor 1 / 0.667
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.663
2xru 400Aurora kinase A 2.7.11.1 0.659
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3e5a VX6Aurora kinase A 2.7.11.1 0.653