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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b8l 5HA Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b8l 5HABeta-secretase 1 3.4.23.46 1.376
4fco 0U4Beta-secretase 1 3.4.23.46 1.313
2p8h MY9Beta-secretase 1 3.4.23.46 1.292
2qzl IXSBeta-secretase 1 3.4.23.46 1.161
2b8v 3BNBeta-secretase 1 3.4.23.46 1.150
2vkm BSDBeta-secretase 1 3.4.23.46 1.146
4gid 0GHBeta-secretase 1 3.4.23.46 1.078
2vj9 VG7Beta-secretase 1 3.4.23.46 1.057
2viz VG4Beta-secretase 1 3.4.23.46 1.055
3i25 MV7Beta-secretase 1 3.4.23.46 1.043
3ixj 586Beta-secretase 1 3.4.23.46 1.043
2vj7 VG6Beta-secretase 1 3.4.23.46 1.040
2xfj VG5Beta-secretase 1 3.4.23.46 1.034
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.027
2xfk AA9Beta-secretase 1 3.4.23.46 1.026
2vj6 VG5Beta-secretase 1 3.4.23.46 1.024
2wf4 ZY4Beta-secretase 1 3.4.23.46 1.023
2vij C44Beta-secretase 1 3.4.23.46 1.020
2vnm CM8Beta-secretase 1 3.4.23.46 1.012
2wf3 ZY3Beta-secretase 1 3.4.23.46 1.011
2xfi XFIBeta-secretase 1 3.4.23.46 1.008
2wez ZYEBeta-secretase 1 3.4.23.46 0.998
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.987
2vnn CM7Beta-secretase 1 3.4.23.46 0.986
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.980
2viy VG3Beta-secretase 1 3.4.23.46 0.971
4dpf 0LGBeta-secretase 1 3.4.23.46 0.971
4dpi 0N1Beta-secretase 1 3.4.23.46 0.963
3dm6 757Beta-secretase 1 3.4.23.46 0.947
2p4j 23IBeta-secretase 1 3.4.23.46 0.936
3tpr 5HABeta-secretase 1 3.4.23.46 0.931
3ixk 929Beta-secretase 1 3.4.23.46 0.924
2irz I02Beta-secretase 1 3.4.23.46 0.902
2is0 I03Beta-secretase 1 3.4.23.46 0.880
3lpj Z75Beta-secretase 1 3.4.23.46 0.879
3k5c 0BIBeta-secretase 1 3.4.23.46 0.877
3cib 314Beta-secretase 1 3.4.23.46 0.874
4ewo 996Beta-secretase 1 3.4.23.46 0.870
3cid 318Beta-secretase 1 3.4.23.46 0.866
3cic 316Beta-secretase 1 3.4.23.46 0.860
3dv5 BAVBeta-secretase 1 3.4.23.46 0.851
3veu 0GOBeta-secretase 1 3.4.23.46 0.850
2iqg F2IBeta-secretase 1 3.4.23.46 0.829
3nsh 957Beta-secretase 1 3.4.23.46 0.829
4i0i 957Beta-secretase 1 3.4.23.46 0.829
4k9h 1QUBeta-secretase 1 3.4.23.46 0.829
2oah QINBeta-secretase 1 3.4.23.46 0.827
3ohh 3HHBeta-secretase 1 3.4.23.46 0.823
4k8s 1QTBeta-secretase 1 3.4.23.46 0.817
3k5g BJCBeta-secretase 1 3.4.23.46 0.815
1tqf 32PBeta-secretase 1 3.4.23.46 0.811
3lpi Z74Beta-secretase 1 3.4.23.46 0.808
4exg 916Beta-secretase 1 3.4.23.46 0.801
2p83 MR0Beta-secretase 1 3.4.23.46 0.793
3r2f PB0Beta-secretase 1 3.4.23.46 0.787
4dh6 0KNBeta-secretase 1 3.4.23.46 0.784
4ke0 1R8Beta-secretase 1 3.4.23.46 0.782
3ohf 3HFBeta-secretase 1 3.4.23.46 0.775
2vie VG0Beta-secretase 1 3.4.23.46 0.766
3qi1 C6ABeta-secretase 1 3.4.23.46 0.752
3k5f AYHBeta-secretase 1 3.4.23.46 0.747
4ke1 1R6Beta-secretase 1 3.4.23.46 0.744
4i0j 842Beta-secretase 1 3.4.23.46 0.739
3pi5 3P5Beta-secretase 1 3.4.23.46 0.727
3n4l 842Beta-secretase 1 3.4.23.46 0.721
3lpk Z76Beta-secretase 1 3.4.23.46 0.713
3qbh QBHBeta-secretase 1 3.4.23.46 0.713
2f3e AXQBeta-secretase 1 3.4.23.46 0.705
3duy AFJBeta-secretase 1 3.4.23.46 0.701
3own 3OWRenin 3.4.23.15 0.699
1gvv 0GMEndothiapepsin 3.4.23.22 0.696
2g94 ZPQBeta-secretase 1 3.4.23.46 0.696
2fdp FRPBeta-secretase 1 3.4.23.46 0.691
3k5d XLIBeta-secretase 1 3.4.23.46 0.689
1psa 0ZLPepsin A 3.4.23.1 0.685
2hiz LIJBeta-secretase 1 3.4.23.46 0.685
2jjj 0QSEndothiapepsin 3.4.23.22 0.682
1w51 L01Beta-secretase 1 3.4.23.46 0.681
2g20 L1ARenin 3.4.23.15 0.677
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.672
1e80 0GQEndothiapepsin 3.4.23.22 0.671
1gvt 2ZSEndothiapepsin 3.4.23.22 0.668
2web PP4Penicillopepsin-1 3.4.23.20 0.668
2jji 0QSEndothiapepsin 3.4.23.22 0.666
1bxq PP8Penicillopepsin-1 3.4.23.20 0.656
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.655