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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b3d FAD Modulator of drug activity B

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b3d FADModulator of drug activity B / 1.420
3rpe FADPutative modulator of drug activity / 1.223
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.848
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.846
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.830
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.822
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.812
4j8p FMNFlavodoxin / 0.810
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.805
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.797
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.793
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.793
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.790
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.778
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.775
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.774
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.763
4utl FNRXenobiotic reductase / 0.757
2q9u FMNA-type flavoprotein / 0.750
2ohh FMNType A flavoprotein FprA 1 0.749
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.730
1ych FMNNitric oxide reductase 1 0.722
3l5l FMNXenobiotic reductase / 0.722
4utm FNRXenobiotic reductase / 0.722
1ycg FMNNitric oxide reductase 1 0.707
4uth FMNXenobiotic reductase / 0.707
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.706
3lcm FADPutative oxidoreductase / 0.704
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.702
1ycf FMNNitric oxide reductase 1 0.701
4jic FMNGTN Reductase / 0.700
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.695
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.690
3f6s FMNFlavodoxin / 0.685
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.685
4bmo FMNProtein NrdI / 0.683
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.683
4tmb FMNOld yellow enzyme / 0.682
4ttc FMNIodotyrosine deiodinase 1 / 0.682
2bn4 FMNNADPH--cytochrome P450 reductase / 0.680
3p74 FMNPentaerythritol tetranitrate reductase / 0.680
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.680
4qly FMNEnone reductase CLA-ER / 0.678
1h51 FMNPentaerythritol tetranitrate reductase / 0.675
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.675
1tll FMNNitric oxide synthase, brain 1.14.13.39 0.673
1h63 FMNPentaerythritol tetranitrate reductase / 0.672
3qe2 FMNNADPH--cytochrome P450 reductase / 0.672
3eo8 FMNPutative nitroreductase / 0.671
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.671
1t0i FMNNAD(P)H-dependent FMN reductase LOT6 / 0.668
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.668
3aty FMNProstaglandin F2a synthase / 0.668
1ofv FMNFlavodoxin / 0.667
4n82 FMNRibonucleotide reductase (NrdI family protein), putative / 0.665
3tjl FMNNADPH dehydrogenase / 0.664
4m5p FMNNADPH dehydrogenase / 0.664
4qai FMNNADPH dehydrogenase / 0.663
1akw FMNFlavodoxin / 0.662
1azl FMNFlavodoxin / 0.662
2abb FMNPentaerythritol tetranitrate reductase / 0.661
3f90 FMNFlavodoxin / 0.661
3gfd FMNIodotyrosine deiodinase 1 1.21.1.1 0.660
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.659
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.659
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.659
4h6p FMNChromate reductase / 0.659
2vig FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.1 0.658
3klb FMNUncharacterized protein / 0.658
4dy4 FMNNAD(P)H dehydrogenase (quinone) / 0.656
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.655
4x28 FDAAcyl-CoA dehydrogenase FadE26 / 0.653
4x28 FDAAcyl-CoA dehydrogenase FadE27 / 0.653
2ifa FMNUncharacterized protein / 0.650
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.650