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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aaz CB3 Thymidylate synthase 2.1.1.45

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aaz CB3Thymidylate synthase 2.1.1.45 1.114
1trg CB3Thymidylate synthase / 0.900
4knz CB3Thymidylate synthase / 0.900
2fto CB3Thymidylate synthase / 0.881
4gev CB3Thymidylate synthase / 0.869
1tys DHFThymidylate synthase / 0.847
2bbq PFGThymidylate synthase / 0.831
1kce CB3Thymidylate synthase / 0.817
1zpr CB3Thymidylate synthase / 0.769
4ez8 DHFThymidylate synthase 2.1.1.45 0.761
2tsc CB3Thymidylate synthase / 0.758
4eil CB3Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.758
2kce D16Thymidylate synthase / 0.757
1dna CB3Thymidylate synthase / 0.736
3bgx MEFThymidylate synthase / 0.723
1ju6 LYAThymidylate synthase 2.1.1.45 0.717
1aiq CB3Thymidylate synthase / 0.716
1tdu CB3Thymidylate synthase / 0.714
1bq1 CB3Thymidylate synthase / 0.710
1nce CB3Thymidylate synthase / 0.674
1fwm CB3Thymidylate synthase / 0.661
1jtq LY3Thymidylate synthase / 0.659
3bhl THGThymidylate synthase / 0.657
1axw MTXThymidylate synthase / 0.655