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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z41 FMN NADPH dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z41 FMNNADPH dehydrogenase / 1.283
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 1.223
3hf3 FMNChromate reductase / 1.185
1z48 FMNNADPH dehydrogenase / 1.179
1z44 FMNNADPH dehydrogenase / 1.167
2gou FMNNADH:flavin oxidoreductase Sye1 / 1.054
3gr8 FMNNADPH dehydrogenase / 1.049
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.032
5cpm FNRNADH:flavin oxidoreductase / 1.003
2h8x FMNXenA / 0.997
3l5l FMNXenobiotic reductase / 0.995
4uth FMNXenobiotic reductase / 0.992
4utm FNRXenobiotic reductase / 0.977
3n14 FMNXenobiotic reductase / 0.969
3n19 FNRXenobiotic reductase / 0.927
4utk FNRXenobiotic reductase / 0.926
4utl FNRXenobiotic reductase / 0.924
3l67 FMNXenobiotic reductase / 0.922
3tjl FMNNADPH dehydrogenase / 0.916
1gwj FMNMorphinone reductase / 0.915
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.915
1vhn FMNtRNA-dihydrouridine synthase / 0.908
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.907
4tmc FMNOld yellow enzyme / 0.905
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.901
1h51 FMNPentaerythritol tetranitrate reductase / 0.895
3p8j FMNPentaerythritol tetranitrate reductase / 0.895
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.894
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.894
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.891
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.887
4jic FMNGTN Reductase / 0.882
2abb FMNPentaerythritol tetranitrate reductase / 0.881
4e2d FMNDehydrogenase / 0.877
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.875
4yco FMNtRNA-dihydrouridine(16) synthase / 0.873
1h63 FMNPentaerythritol tetranitrate reductase / 0.871
3atz FMNProstaglandin F2a synthase / 0.870
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.868
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.867
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.865
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.864
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.862
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.860
3p8i FMNPentaerythritol tetranitrate reductase / 0.855
1vyr FMNPentaerythritol tetranitrate reductase / 0.854
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.852
3gka FMNN-ethylmaleimide reductase / 0.849
4qai FMNNADPH dehydrogenase / 0.849
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.848
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.847
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.846
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.843
3f03 FMNPentaerythritol tetranitrate reductase / 0.842
3p84 FMNPentaerythritol tetranitrate reductase / 0.842
1h50 FMNPentaerythritol tetranitrate reductase / 0.839
4tmb FMNOld yellow enzyme / 0.835
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.831
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.831
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.826
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.826
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.822
3p67 FMNPentaerythritol tetranitrate reductase / 0.819
4e2b FMNDehydrogenase / 0.814
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.813
2zfa FMNLactate oxidase / 0.810
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.805
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.804
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.800
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.798
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.797
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.797
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.790
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.789
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.786
4df2 FMNNADPH dehydrogenase / 0.785
2nli FMNLactate oxidase / 0.781
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.778
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.773
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.772
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.768
4m5p FMNNADPH dehydrogenase / 0.758
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.757
3p62 FMNPentaerythritol tetranitrate reductase / 0.754
3p74 FMNPentaerythritol tetranitrate reductase / 0.754
4cw5 FMNDfnA / 0.752
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.751
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.751
2j6x FMNLactate oxidase / 0.750
3p82 FMNPentaerythritol tetranitrate reductase / 0.749
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.746
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.745
4yl2 FMNLactate oxidase / 0.745
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.742
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.735
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.735
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.726
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.723
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.714
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.711
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.710
3oix FMNDihydroorotate dehydrogenase / 0.709
2gjl FMNNitronate monooxygenase 1.13.12.16 0.708
2z6i FMN2-nitropropane dioxygenase / 0.702
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.702
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.699
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.699
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.693
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.688
4bc7 FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.686
2du2 FMNLactate oxidase / 0.682
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.681
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.678
2e77 FMNLactate oxidase / 0.677
4z38 FMNMlnA / 0.676
5j4e FMNSensory box protein / 0.672
2vyx FMNDodecin / 0.670
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.668
3qfr FMNNADPH--cytochrome P450 reductase / 0.668
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.667
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.665
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.663
4rje FNRLactate oxidase / 0.663
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.661
3n3b FMNProtein NrdI / 0.659
3fst FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.655
3w8w FADPutative FAD-dependent oxygenase EncM / 0.653
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.652
2eba FADPutative glutaryl-CoA dehydrogenase / 0.651
2ohj FMNType A flavoprotein FprA 1 0.650
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.650