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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z3n 3NA Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z3n 3NAAldose reductase 1.1.1.21 1.241
4gca 2X9Aldose reductase 1.1.1.21 1.085
2duz ZSTAldose reductase 1.1.1.21 0.928
2pd5 ZSTAldose reductase 1.1.1.21 0.927
2pdq 47DAldose reductase 1.1.1.21 0.918
2dv0 ZSTAldose reductase 1.1.1.21 0.917
2pdg 47DAldose reductase 1.1.1.21 0.917
2dux ZSTAldose reductase 1.1.1.21 0.905
2pdb ZSTAldose reductase 1.1.1.21 0.899
3g5e Q74Aldose reductase 1.1.1.21 0.891
2fz9 ZSTAldose reductase 1.1.1.21 0.871
2pdn 47DAldose reductase 1.1.1.21 0.868
2fz8 ZSTAldose reductase 1.1.1.21 0.867
1t41 ID5Aldose reductase 1.1.1.21 0.861
2pdi ZSTAldose reductase 1.1.1.21 0.833
1frb ZSTAldose reductase-related protein 2 / 0.830
2hvn ZSTAldose reductase 1.1.1.21 0.829
2hv5 ZSTAldose reductase 1.1.1.21 0.768
2pdm ZSTAldose reductase 1.1.1.21 0.767
1t40 ID5Aldose reductase 1.1.1.21 0.765
3lbo LDTAldose reductase 1.1.1.21 0.765
2hvo ZSTAldose reductase 1.1.1.21 0.758
2pdx ZSTAldose reductase 1.1.1.21 0.758
2ikj 393Aldose reductase 1.1.1.21 0.741
3m4h 388Aldose reductase 1.1.1.21 0.729
3ght LDTAldose reductase 1.1.1.21 0.727
2pzn 393Aldose reductase 1.1.1.21 0.725
3ghu LDTAldose reductase 1.1.1.21 0.722
3t42 3T4Aldose reductase 1.1.1.21 0.721
1iei ZESAldose reductase 1.1.1.21 0.716
2pdc 393Aldose reductase 1.1.1.21 0.712
3mc5 393Aldose reductase 1.1.1.21 0.712
3m64 393Aldose reductase 1.1.1.21 0.710
3m0i ZSTAldose reductase 1.1.1.21 0.707
3len ZSTAldose reductase 1.1.1.21 0.701
2nvc ITAAldose reductase 1.1.1.21 0.687
2pdp 393Aldose reductase 1.1.1.21 0.685
2pdu 393Aldose reductase 1.1.1.21 0.683
2pdf ZSTAldose reductase 1.1.1.21 0.676
3mb9 ZSTAldose reductase 1.1.1.21 0.665
4dwv PFBAlcohol dehydrogenase E chain 1.1.1.1 0.651