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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xf0 ASD Aldo-keto reductase family 1 member C3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1xf0 ASDAldo-keto reductase family 1 member C3 / 1.103
3s79 ASDAromatase 1.14.14.14 0.763
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2ylp TESAndrogen receptor / 0.708
1p8d CO1Oxysterols receptor LXR-beta / 0.705
4ofr DHTAndrogen receptor / 0.705
2piw DHTAndrogen receptor / 0.704
4l1x STRAldo-keto reductase family 1 member C2 / 0.700
2aa7 1CAMineralocorticoid receptor / 0.696
2q7k TESAndrogen receptor / 0.695
2ylo TESAndrogen receptor / 0.694
2j7x ESTEstrogen receptor beta / 0.691
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.689
2piu DHTAndrogen receptor / 0.687
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.685
1gs4 ZK5Androgen receptor / 0.684
2w8y NDRProgesterone receptor / 0.682
5hyr ESTEstrogen receptor / 0.682
2qgt EEDEstrogen receptor / 0.681
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.678
4j26 ESTEstrogen receptor beta / 0.676
1t7r DHTAndrogen receptor / 0.674
3uud ESTEstrogen receptor / 0.672
2g5o DRQEstrogen receptor / 0.671
5dx3 ESTEstrogen receptor / 0.671
5dxg ESTEstrogen receptor / 0.671
2pkl DHTAndrogen receptor / 0.669
2yhd TESAndrogen receptor / 0.669
4pxm ESTEstrogen receptor / 0.668
1gwr ESTEstrogen receptor / 0.667
2aax PDNMineralocorticoid receptor / 0.667
1t5z DHTAndrogen receptor / 0.665
2q7l TESAndrogen receptor / 0.664
1lhu ESTSex hormone-binding globulin / 0.663
1lri CLRBeta-elicitin cryptogein / 0.663
2pip DHTAndrogen receptor / 0.663
4hlw TESAndrogen receptor / 0.662
4oez DHTAndrogen receptor / 0.662
1t76 DHTAndrogen receptor / 0.661
2pio DHTAndrogen receptor / 0.661
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2aa2 AS4Mineralocorticoid receptor / 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z4j DHTAndrogen receptor / 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pnu ENMAndrogen receptor / 0.659
1zhw HC2Oxysterol-binding protein homolog 4 / 0.658
4jbt ASDCytochrome P450 monooxygenase / 0.658
1t73 DHTAndrogen receptor / 0.657
2ylq TESAndrogen receptor / 0.657
2b04 CHOPhospholipase A2, major isoenzyme 3.1.1.4 0.655
3q95 ESLEstrogen receptor / 0.655
4j6b PLOCytochrome P450 monooxygenase / 0.654
1g50 ESTEstrogen receptor / 0.653
4udc DEXGlucocorticoid receptor / 0.653
2ocf ESTEstrogen receptor / 0.652
4at2 ASDPossible succinate dehydrogenase / 0.651
1xj7 DHTAndrogen receptor / 0.650
2yja ESTEstrogen receptor / 0.650