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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w8c N69 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1w8c N69Cyclin-dependent kinase 2 2.7.11.22 0.909
1gz8 MBPCyclin-dependent kinase 2 2.7.11.22 0.707
3r8u Z31Cyclin-dependent kinase 2 2.7.11.22 0.694
1oiu N76Cyclin-dependent kinase 2 2.7.11.22 0.683
2c69 CT8Cyclin-dependent kinase 2 2.7.11.22 0.683
3rpr 25ZCyclin-dependent kinase 2 2.7.11.22 0.677
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.670
3rk9 09ZCyclin-dependent kinase 2 2.7.11.22 0.668
3qyw 6PBMitogen-activated protein kinase 1 2.7.11.24 0.667
3rkb 12ZCyclin-dependent kinase 2 2.7.11.22 0.667
3rvg 17PTyrosine-protein kinase JAK2 / 0.659
2c68 CT6Cyclin-dependent kinase 2 2.7.11.22 0.658
3qtz X42Cyclin-dependent kinase 2 2.7.11.22 0.654
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.652
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.652
1u54 ACPActivated CDC42 kinase 1 / 0.652
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.651
3qwj X6ACyclin-dependent kinase 2 2.7.11.22 0.651
3qzi X72Cyclin-dependent kinase 2 2.7.11.22 0.650
3r8v Z62Cyclin-dependent kinase 2 2.7.11.22 0.650