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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w51 L01 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1w51 L01Beta-secretase 1 3.4.23.46 1.131
3lpj Z75Beta-secretase 1 3.4.23.46 0.877
2iqg F2IBeta-secretase 1 3.4.23.46 0.870
3cib 314Beta-secretase 1 3.4.23.46 0.870
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.862
2viy VG3Beta-secretase 1 3.4.23.46 0.860
3ohf 3HFBeta-secretase 1 3.4.23.46 0.843
3lpi Z74Beta-secretase 1 3.4.23.46 0.837
4dpi 0N1Beta-secretase 1 3.4.23.46 0.836
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.834
2vnn CM7Beta-secretase 1 3.4.23.46 0.832
2hm1 LIQBeta-secretase 1 3.4.23.46 0.827
2vj6 VG5Beta-secretase 1 3.4.23.46 0.826
2vnm CM8Beta-secretase 1 3.4.23.46 0.824
2vie VG0Beta-secretase 1 3.4.23.46 0.821
4k9h 1QUBeta-secretase 1 3.4.23.46 0.820
3cid 318Beta-secretase 1 3.4.23.46 0.818
3k5g BJCBeta-secretase 1 3.4.23.46 0.813
2viz VG4Beta-secretase 1 3.4.23.46 0.812
2p83 MR0Beta-secretase 1 3.4.23.46 0.810
3cic 316Beta-secretase 1 3.4.23.46 0.804
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.802
2b8v 3BNBeta-secretase 1 3.4.23.46 0.801
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.800
2xfj VG5Beta-secretase 1 3.4.23.46 0.797
2xfk AA9Beta-secretase 1 3.4.23.46 0.793
3vf3 0GSBeta-secretase 1 3.4.23.46 0.789
3lpk Z76Beta-secretase 1 3.4.23.46 0.788
4dpf 0LGBeta-secretase 1 3.4.23.46 0.784
2xfi XFIBeta-secretase 1 3.4.23.46 0.783
4ke1 1R6Beta-secretase 1 3.4.23.46 0.774
2vij C44Beta-secretase 1 3.4.23.46 0.773
2vj9 VG7Beta-secretase 1 3.4.23.46 0.771
2fdp FRPBeta-secretase 1 3.4.23.46 0.770
4lxk 1YTBeta-secretase 1 3.4.23.46 0.769
4lxa 1YSBeta-secretase 1 3.4.23.46 0.766
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.762
3qbh QBHBeta-secretase 1 3.4.23.46 0.762
3ohh 3HHBeta-secretase 1 3.4.23.46 0.759
4d89 BXDBeta-secretase 1 3.4.23.46 0.755
3pi5 3P5Beta-secretase 1 3.4.23.46 0.753
4lxm 1YUBeta-secretase 1 3.4.23.46 0.752
3vg1 0GTBeta-secretase 1 3.4.23.46 0.742
2hiz LIJBeta-secretase 1 3.4.23.46 0.740
2vkm BSDBeta-secretase 1 3.4.23.46 0.740
3pww ROCEndothiapepsin 3.4.23.22 0.736
3tpr 5HABeta-secretase 1 3.4.23.46 0.725
4k8s 1QTBeta-secretase 1 3.4.23.46 0.723
4dus 0MPBeta-secretase 1 3.4.23.46 0.721
3ixj 586Beta-secretase 1 3.4.23.46 0.707
2p8h MY9Beta-secretase 1 3.4.23.46 0.705
2g94 ZPQBeta-secretase 1 3.4.23.46 0.704
3i25 MV7Beta-secretase 1 3.4.23.46 0.704
4fco 0U4Beta-secretase 1 3.4.23.46 0.702
3k5f AYHBeta-secretase 1 3.4.23.46 0.693
3skg PB8Beta-secretase 1 3.4.23.46 0.693
3ixk 929Beta-secretase 1 3.4.23.46 0.692
4gid 0GHBeta-secretase 1 3.4.23.46 0.688
2f3e AXQBeta-secretase 1 3.4.23.46 0.684
2f3f AXFBeta-secretase 1 3.4.23.46 0.683
3dm6 757Beta-secretase 1 3.4.23.46 0.683
3veu 0GOBeta-secretase 1 3.4.23.46 0.682
4dh6 0KNBeta-secretase 1 3.4.23.46 0.682
2b8l 5HABeta-secretase 1 3.4.23.46 0.681
2vj7 VG6Beta-secretase 1 3.4.23.46 0.678
3k5c 0BIBeta-secretase 1 3.4.23.46 0.672
3qi1 C6ABeta-secretase 1 3.4.23.46 0.672
2jji 0QSEndothiapepsin 3.4.23.22 0.670
4exg 916Beta-secretase 1 3.4.23.46 0.666
1gvv 0GMEndothiapepsin 3.4.23.22 0.664
3dv5 BAVBeta-secretase 1 3.4.23.46 0.656
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.654
1bxq PP8Penicillopepsin-1 3.4.23.20 0.653
1e81 M91Endothiapepsin 3.4.23.22 0.652
2wez ZYEBeta-secretase 1 3.4.23.46 0.652
1bxo PP7Penicillopepsin-1 3.4.23.20 0.650