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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uk1 FRQ Poly [ADP-ribose] polymerase 1 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uk1 FRQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.982
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.694
3l3l L3LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.692
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.671
4tjy 3GNTankyrase-2 2.4.2.30 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.652
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.652