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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u4g HPI Elastase 3.4.24.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u4g HPIElastase 3.4.24.26 1.176
3fv4 1U4Thermolysin 3.4.24.27 0.802
4cth RDFNeprilysin / 0.767
1r1j OIRNeprilysin / 0.762
3t87 UBZThermolysin 3.4.24.27 0.752
3t74 UBYThermolysin 3.4.24.27 0.744
3t8c UBWThermolysin 3.4.24.27 0.737
4tmn 0PKThermolysin 3.4.24.27 0.736
3t8h UBSThermolysin 3.4.24.27 0.732
3t8d UBVThermolysin 3.4.24.27 0.731
3zuk RDFEndopeptidase, peptidase family M13 / 0.715
4d9w X32Thermolysin 3.4.24.27 0.712
4h57 0PJThermolysin 3.4.24.27 0.711
3fvp UB2Thermolysin 3.4.24.27 0.707
1r1i TI1Neprilysin / 0.695
2tmn 0FAThermolysin 3.4.24.27 0.692
2x95 X95Angiotensin-converting enzyme 3.4.15.1 0.692
1j36 LPRAngiotensin-converting enzyme 3.4.15.1 0.689
4b52 RDFBacillolysin / 0.683
1qf2 TI3Thermolysin 3.4.24.27 0.672
2x93 X93Angiotensin-converting enzyme 3.4.15.1 0.670
4zr5 RDFNeprilysin / 0.670
2x94 X94Angiotensin-converting enzyme 3.4.15.1 0.669
1r4l XX5Angiotensin-converting enzyme 2 3.4.17.23 0.660
2x91 LPRAngiotensin-converting enzyme 3.4.15.1 0.658
3dwb RDFEndothelin-converting enzyme 1 3.4.24.71 0.656