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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tsv UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tsv UMPThymidylate synthase / 1.067
2tdm UMPThymidylate synthase / 0.922
1bp6 UMPThymidylate synthase / 0.884
1njd UMPThymidylate synthase / 0.862
1tsy UMPThymidylate synthase / 0.858
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.858
1njc DCMThymidylate synthase / 0.831
1bid UMPThymidylate synthase / 0.826
1tsx UMPThymidylate synthase / 0.820
2g8a UMPThymidylate synthase / 0.817
2g8d UMPThymidylate synthase / 0.815
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.810
2g86 UMPThymidylate synthase / 0.808
1bp0 UMPThymidylate synthase / 0.804
1vzb UMPThymidylate synthase / 0.799
2g89 UMPThymidylate synthase / 0.787
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.778
5by6 UMPThymidylate synthase / 0.777
1nja DCMThymidylate synthase / 0.765
1jmh UMPThymidylate synthase / 0.761
1njb UMPThymidylate synthase / 0.750
2fto TMPThymidylate synthase / 0.745
1bpj UMPThymidylate synthase / 0.739
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.731
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.726
1tdu DURThymidylate synthase / 0.724
4fox UMPThymidylate synthase ThyA / 0.721
2vet UMPThymidylate synthase / 0.719
1f28 UMPThymidylate synthase 2.1.1.45 0.718
1jmf UMPThymidylate synthase / 0.713
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.712
4ein NOHThymidylate synthase 2.1.1.45 0.706
1tdc UMPThymidylate synthase / 0.703
1ddu DDUThymidylate synthase / 0.702
1tys TMPThymidylate synthase / 0.701
4dq1 UMPThymidylate synthase / 0.699
4iqq UMPThymidylate synthase / 0.698
4e5o UMPThymidylate synthase 2.1.1.45 0.697
4psg NOHThymidylate synthase / 0.697
4isk UMPThymidylate synthase / 0.692
1nje DCMThymidylate synthase / 0.691
1vza UMPThymidylate synthase / 0.690
1jmi UMPThymidylate synthase / 0.676
2x1e X1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form 2.3.1.164 0.675
3bgx TMPThymidylate synthase / 0.675
4cnz ADPNitrogen regulatory protein P-II 1 / 0.674
1bdu DURThymidylate synthase / 0.671
2vwq NAPGlucose 1-dehydrogenase / 0.670
2vwh NAPGlucose 1-dehydrogenase / 0.668
1mo9 KPC2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.662
2q0l NAPThioredoxin reductase 1.8.1.9 0.660
3qj7 UMPThymidylate synthase ThyA / 0.658
4ocg COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.656
4eb4 UMPThymidylate synthase 2.1.1.45 0.655
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.654