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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tdc UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tdc UMPThymidylate synthase / 0.926
4eb4 UMPThymidylate synthase 2.1.1.45 0.731
1vza UMPThymidylate synthase / 0.725
2vet UMPThymidylate synthase / 0.724
1tsv UMPThymidylate synthase / 0.703
1tsy UMPThymidylate synthase / 0.702
1f28 UMPThymidylate synthase 2.1.1.45 0.701
1njc DCMThymidylate synthase / 0.701
4irr UMPThymidylate synthase / 0.700
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.699
1vzb UMPThymidylate synthase / 0.697
4e5o UMPThymidylate synthase 2.1.1.45 0.695
4isk UMPThymidylate synthase / 0.694
2tdm UMPThymidylate synthase / 0.690
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.689
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.688
1nja DCMThymidylate synthase / 0.687
2fto TMPThymidylate synthase / 0.681
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.680
2g8a UMPThymidylate synthase / 0.676
1jmf UMPThymidylate synthase / 0.675
4ein NOHThymidylate synthase 2.1.1.45 0.674
1jmi UMPThymidylate synthase / 0.670
2tsr UMPThymidylate synthase 2.1.1.45 0.670
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.669
4iqq UMPThymidylate synthase / 0.667
1bpj UMPThymidylate synthase / 0.665
1nje DCMThymidylate synthase / 0.663
2g86 UMPThymidylate synthase / 0.663
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.662
1tdu DURThymidylate synthase / 0.661
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.659
2vp2 DGTDeoxynucleoside kinase / 0.655
1tys TMPThymidylate synthase / 0.654
4dq1 UMPThymidylate synthase / 0.653