Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx8 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx8 FOLDihydrofolate reductase 1.5.1.3 1.008
1drf FOLDihydrofolate reductase 1.5.1.3 0.801
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.770
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.758
1dyh DZFDihydrofolate reductase 1.5.1.3 0.751
4i13 FOLDihydrofolate reductase 1.5.1.3 0.751
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.746
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.742
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.742
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.737
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.737
4i1n FOLDihydrofolate reductase 1.5.1.3 0.729
4kfj FOLDihydrofolate reductase 1.5.1.3 0.726
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.724
1dyi FOLDihydrofolate reductase 1.5.1.3 0.723
4fhb FOLDihydrofolate reductase 1.5.1.3 0.722
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.722
4x5g FOLDihydrofolate reductase 1.5.1.3 0.718
1dhf FOLDihydrofolate reductase 1.5.1.3 0.712
4qi9 MTXDihydrofolate reductase / 0.712
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.708
3dfr MTXDihydrofolate reductase 1.5.1.3 0.707
4x5h FOLDihydrofolate reductase 1.5.1.3 0.707
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.706
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.704
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.702
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.701
1df7 MTXDihydrofolate reductase 1.5.1.3 0.698
4kjj FOLDihydrofolate reductase 1.5.1.3 0.697
4x5i FOLDihydrofolate reductase 1.5.1.3 0.697
2zza FOLDihydrofolate reductase / 0.696
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.696
7dfr FOLDihydrofolate reductase 1.5.1.3 0.695
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.694
4keb FOLDihydrofolate reductase 1.5.1.3 0.693
1hfq MOTDihydrofolate reductase 1.5.1.3 0.692
3dau MTXDihydrofolate reductase 1.5.1.3 0.690
1drb MTXDihydrofolate reductase 1.5.1.3 0.689
1dhi MTXDihydrofolate reductase 1.5.1.3 0.688
4m6k FOLDihydrofolate reductase 1.5.1.3 0.688
5ccc DDFDihydrofolate reductase 1.5.1.3 0.686
1dre MTXDihydrofolate reductase 1.5.1.3 0.685
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.685
1tdr MTXDihydrofolate reductase 1.5.1.3 0.685
4x5f FOLDihydrofolate reductase 1.5.1.3 0.684
1dyj DDFDihydrofolate reductase 1.5.1.3 0.683
1ohj COPDihydrofolate reductase 1.5.1.3 0.681
2w3m FOLDihydrofolate reductase 1.5.1.3 0.681
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.681
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.680
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.680
3tqb FOLDihydrofolate reductase / 0.679
1hfr MOTDihydrofolate reductase 1.5.1.3 0.678
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.678
4p68 MTXDihydrofolate reductase / 0.678
1ddr MTXDihydrofolate reductase 1.5.1.3 0.674
2d0k FOLDihydrofolate reductase 1.5.1.3 0.674
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.672
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.670
2ahc VNLChorismate pyruvate-lyase / 0.670
4l8u 9AZSerum albumin / 0.670
1jom FFODihydrofolate reductase 1.5.1.3 0.669
1ohk COPDihydrofolate reductase 1.5.1.3 0.666
1hfp MOTDihydrofolate reductase 1.5.1.3 0.664
3td8 D2RDihydrofolate reductase 1.5.1.3 0.664
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.663
1u72 MTXDihydrofolate reductase 1.5.1.3 0.663
3och 2MXDihydrofolate reductase 1.5.1.3 0.663
1toi HCIAspartate aminotransferase 2.6.1.1 0.659
1hbm SHTMethyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.658
1hbm SHTMethyl-coenzyme M reductase I subunit beta 2.8.4.1 0.658
5hi6 MTXDihydrofolate reductase / 0.658
3frd DHFDihydrofolate reductase 1.5.1.3 0.656
1toj HCIAspartate aminotransferase 2.6.1.1 0.655
3eig MTXDihydrofolate reductase 1.5.1.3 0.655
4x5j FOLDihydrofolate reductase 1.5.1.3 0.653
1re7 FOLDihydrofolate reductase 1.5.1.3 0.652
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.651
3tq9 MTXDihydrofolate reductase / 0.651
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.651