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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rg7 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rg7 MTXDihydrofolate reductase 1.5.1.3 1.036
3dau MTXDihydrofolate reductase 1.5.1.3 0.930
3drc MTXDihydrofolate reductase 1.5.1.3 0.917
1df7 MTXDihydrofolate reductase 1.5.1.3 0.895
4dfr MTXDihydrofolate reductase 1.5.1.3 0.895
5hi6 MTXDihydrofolate reductase / 0.891
3och 2MXDihydrofolate reductase 1.5.1.3 0.887
2drc MTXDihydrofolate reductase 1.5.1.3 0.882
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.880
4qi9 MTXDihydrofolate reductase / 0.873
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.868
1dhi MTXDihydrofolate reductase 1.5.1.3 0.863
1dra MTXDihydrofolate reductase 1.5.1.3 0.863
1tdr MTXDihydrofolate reductase 1.5.1.3 0.861
1drb MTXDihydrofolate reductase 1.5.1.3 0.857
3ia4 MTXDihydrofolate reductase / 0.857
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.850
4p66 MTXDihydrofolate reductase / 0.842
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.841
1dre MTXDihydrofolate reductase 1.5.1.3 0.834
1ohj COPDihydrofolate reductase 1.5.1.3 0.832
3eig MTXDihydrofolate reductase 1.5.1.3 0.830
2qk8 MTXDihydrofolate reductase / 0.828
1dls MTXDihydrofolate reductase 1.5.1.3 0.827
1dyj DDFDihydrofolate reductase 1.5.1.3 0.822
3dfr MTXDihydrofolate reductase 1.5.1.3 0.822
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.820
1u70 MTXDihydrofolate reductase 1.5.1.3 0.813
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.808
1dhj MTXDihydrofolate reductase 1.5.1.3 0.798
4x5h FOLDihydrofolate reductase 1.5.1.3 0.797
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.790
1u72 MTXDihydrofolate reductase 1.5.1.3 0.790
1jom FFODihydrofolate reductase 1.5.1.3 0.786
3tq9 MTXDihydrofolate reductase / 0.786
1jol FFODihydrofolate reductase 1.5.1.3 0.784
4p68 MTXDihydrofolate reductase / 0.780
4x5i FOLDihydrofolate reductase 1.5.1.3 0.775
4i1n FOLDihydrofolate reductase 1.5.1.3 0.774
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.773
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.772
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.771
4kjj FOLDihydrofolate reductase 1.5.1.3 0.769
4x5f FOLDihydrofolate reductase 1.5.1.3 0.769
1dyi FOLDihydrofolate reductase 1.5.1.3 0.767
1e26 GPBDihydrofolate reductase 1.5.1.3 0.767
1dyh DZFDihydrofolate reductase 1.5.1.3 0.762
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.760
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.758
4m6k FOLDihydrofolate reductase 1.5.1.3 0.758
1drf FOLDihydrofolate reductase 1.5.1.3 0.755
4i13 FOLDihydrofolate reductase 1.5.1.3 0.749
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.746
1hfq MOTDihydrofolate reductase 1.5.1.3 0.745
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.745
2zza FOLDihydrofolate reductase / 0.745
4kfj FOLDihydrofolate reductase 1.5.1.3 0.744
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.742
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.742
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.740
2d0k FOLDihydrofolate reductase 1.5.1.3 0.740
4keb FOLDihydrofolate reductase 1.5.1.3 0.740
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.738
3frd DHFDihydrofolate reductase 1.5.1.3 0.737
2w3m FOLDihydrofolate reductase 1.5.1.3 0.735
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.733
1hfr MOTDihydrofolate reductase 1.5.1.3 0.733
7dfr FOLDihydrofolate reductase 1.5.1.3 0.733
4x5g FOLDihydrofolate reductase 1.5.1.3 0.730
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.729
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.728
1hfp MOTDihydrofolate reductase 1.5.1.3 0.725
3dat MTXDihydrofolate reductase / 0.720
5ccc DDFDihydrofolate reductase 1.5.1.3 0.719
1re7 FOLDihydrofolate reductase 1.5.1.3 0.716
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.702
1dds MTXDihydrofolate reductase 1.5.1.3 0.700
2dhf DZFDihydrofolate reductase 1.5.1.3 0.700
3ghv GHCDihydrofolate reductase 1.5.1.3 0.697
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.697
3tqb FOLDihydrofolate reductase / 0.697
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.696
1dhf FOLDihydrofolate reductase 1.5.1.3 0.694
4fhb FOLDihydrofolate reductase 1.5.1.3 0.692
4m7v RARDihydrofolate reductase / 0.690
4m6l 21VDihydrofolate reductase 1.5.1.3 0.687
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.685
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.685
4elb 34SDihydrofolate reductase / 0.684
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.683
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.678
2w9g TOPDihydrofolate reductase 1.5.1.3 0.674
1ddr MTXDihydrofolate reductase 1.5.1.3 0.672
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.671
3ghw GHWDihydrofolate reductase 1.5.1.3 0.670
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.670
3td8 D2RDihydrofolate reductase 1.5.1.3 0.669
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.664
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.662
4elf 35IDihydrofolate reductase / 0.660
1daj MOTDihydrofolate reductase 1.5.1.3 0.657
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.656
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.653
3zzf NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.653
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.652
1ohk COPDihydrofolate reductase 1.5.1.3 0.651
4bqy FNTEgl nine homolog 1 / 0.650