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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rej B1L cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.182
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.978
1sve I01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
1svh I08cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
1bx6 BA1cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1svg I04cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
5av0 47XDeath-associated protein kinase 1 2.7.11.1 0.723
1xh4 R69cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1xh9 R69cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.687
1xh6 R94cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4agu D15Cyclin-dependent kinase-like 1 / 0.678
3f88 3HTGlycogen synthase kinase-3 beta 2.7.11.26 0.677
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.669
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.669
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.668
1xh5 R68cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.661
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.657
4zn7 DESEstrogen receptor / 0.657
2ojf 4PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2vo3 M04cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
2xj2 985Serine/threonine-protein kinase pim-1 2.7.11.1 0.654
4kin 1M8Mitogen-activated protein kinase 14 / 0.652
5av4 GENDeath-associated protein kinase 1 2.7.11.1 0.652
4eh7 0OOMitogen-activated protein kinase 14 / 0.651
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.650