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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qsn COA HAT A1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qsn COAHAT A1 / 1.094
1pu9 COAHAT A1 / 1.027
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.909
1qsr ACOHAT A1 / 0.877
1pua COAHAT A1 / 0.830
1kuv CA5Serotonin N-acetyltransferase / 0.804
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.799
2ozu ACOHistone acetyltransferase KAT6A / 0.786
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.782
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.776
1wwz ACOUncharacterized protein / 0.775
1l0c COTSerotonin N-acetyltransferase / 0.763
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.762
1m1d LYXHAT A1 / 0.762
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.760
1mjb ACOHistone acetyltransferase ESA1 / 0.759
5kf8 ACOPredicted acetyltransferase / 0.756
2ou2 ACOHistone acetyltransferase KAT5 / 0.755
5kf1 ACOPredicted acetyltransferase / 0.748
5kgj ACOPredicted acetyltransferase / 0.747
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.745
5kf9 ACOPredicted acetyltransferase / 0.745
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.737
1ib1 COTSerotonin N-acetyltransferase / 0.736
3mgd ACOPredicted acetyltransferase / 0.736
2rc4 ACOHistone acetyltransferase KAT6A / 0.734
1mj9 COAHistone acetyltransferase ESA1 / 0.732
5kgp ACOPredicted acetyltransferase / 0.727
3sxn COAN-acetyltransferase Eis / 0.725
5kf2 COAPredicted acetyltransferase / 0.725
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.722
1cjw COTSerotonin N-acetyltransferase / 0.721
4r3k COAN-alpha-acetyltransferase 2.3.1 0.716
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.715
1kuy COTSerotonin N-acetyltransferase / 0.713
2r8v ACOAmino-acid acetyltransferase / 0.712
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.712
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.710
5kf9 COAPredicted acetyltransferase / 0.708
1n71 COAAac(6')-Ii protein / 0.706
2x7b COAN-alpha-acetyltransferase 2.3.1 0.703
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.701
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.698
1fy7 COAHistone acetyltransferase ESA1 / 0.697
1mja COAHistone acetyltransferase ESA1 / 0.697
2cns ACORibosomal-protein-alanine acetyltransferase / 0.696
3f8k COAUncharacterized protein / 0.694
4u9y COAAlpha-tubulin N-acetyltransferase 1 / 0.688
2cnt COARibosomal-protein-alanine acetyltransferase / 0.687
1s7n COAAcetyl transferase / 0.685
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.684
5kf1 COAPredicted acetyltransferase / 0.681
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.671
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.670
4qvt ACOAcetyltransferase YpeA 2.3.1 0.670
3pgp ACOUncharacterized protein / 0.668
4kub COAUncharacterized protein / 0.665
2ge3 ACOProbable acetyltransferase / 0.663
1qsm ACOHistone acetyltransferase HPA2 / 0.662
2jdd ACOProbable acetyltransferase / 0.661
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.661
1j4j ACOAcetyltransferase 2.3.1 0.658
3d2p COAAmino-acid acetyltransferase / 0.658
2jev NHQDiamine acetyltransferase 1 / 0.657
5kf8 COAPredicted acetyltransferase / 0.655
4a31 MYAGlycylpeptide N-tetradecanoyltransferase / 0.653
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.653
4ag9 COAGlucosamine 6-phosphate N-acetyltransferase / 0.651
2wsa MYAGlycylpeptide N-tetradecanoyltransferase / 0.650