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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qpj STU Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 1.056
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.876
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.821
1byg STUTyrosine-protein kinase CSK / 0.801
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.797
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.794
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.791
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.789
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.785
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.774
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.772
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
1xjd STUProtein kinase C theta type 2.7.11.13 0.768
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.761
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.754
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.745
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3zew STUEphrin type-B receptor 4 2.7.10.1 0.741
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.739
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.739
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.727
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.721
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.720
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.720
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.718
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.714
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.707
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.707
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.706
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.698
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.695
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.694
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.684
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.683
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.680
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.677
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.677
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.674
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.670
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.666
4e5f 0N7Polymerase acidic protein / 0.660
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.655
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.651
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.650
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.650