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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qcf PP1 Tyrosine-protein kinase HCK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.974
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 0.853
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.846
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.840
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.791
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.784
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.781
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.775
3vs0 VS0Tyrosine-protein kinase HCK 2.7.10.2 0.757
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.752
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.732
2zv9 PP2Tyrosine-protein kinase Lyn 2.7.10.2 0.727
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.708
4yuq KS1Calmodulin-like domain protein kinase / 0.694
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.684
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.675
3vs1 VSATyrosine-protein kinase HCK 2.7.10.2 0.670
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.662
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3mwu BK3Calmodulin-domain protein kinase 1, putative / 0.655
3vs6 VSHTyrosine-protein kinase HCK 2.7.10.2 0.652
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.652