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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1p6x THM Thymidine kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1p6x THMThymidine kinase / 1.061
1p72 THMThymidine kinase / 0.947
2vp0 TTPDeoxynucleoside kinase / 0.736
2jcs TTPDeoxynucleoside kinase / 0.734
1zm7 TTPDeoxynucleoside kinase / 0.723
1oe0 TTPDeoxynucleoside kinase / 0.710
1e2l TMCThymidine kinase / 0.708
2jj8 AZZDeoxynucleoside kinase / 0.682
1e2j THMThymidine kinase / 0.679
2qg4 UGAUDP-glucose 6-dehydrogenase 1.1.1.22 0.679
3khu UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.677
1ux0 THUCytidine deaminase 3.5.4.5 0.668
3px3 T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase 2.1.1.235 0.667
1e2k TMCThymidine kinase / 0.662
1jtk THUCytidine deaminase 3.5.4.5 0.662
2vqs BVDDeoxynucleoside kinase / 0.662
2y0d UGAUDP-glucose dehydrogenase / 0.658
2q3e UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.655
1dli UDXUDP-glucose 6-dehydrogenase / 0.653
1n5i TMPThymidylate kinase 2.7.4.9 0.653
3iaa TYDCalG2 / 0.652