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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o5g CR9 Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o5g CR9Prothrombin 3.4.21.5 1.100
1gj4 132Prothrombin 3.4.21.5 0.786
1o2g 696Prothrombin 3.4.21.5 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1ghv 120Prothrombin 3.4.21.5 0.726
4fuf 8UPUrokinase-type plasminogen activator 3.4.21.73 0.714
1c1w BAHProthrombin 3.4.21.5 0.712
4fud 6UPUrokinase-type plasminogen activator 3.4.21.73 0.707
1oyt FSNProthrombin 3.4.21.5 0.706
4az2 9MUProthrombin 3.4.21.5 0.705
2bok 784Coagulation factor X 3.4.21.6 0.698
1owd 497Urokinase-type plasminogen activator 3.4.21.73 0.697
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.691
2v3h I25Prothrombin 3.4.21.5 0.690
3biv 11UProthrombin 3.4.21.5 0.687
1sqt UI3Urokinase-type plasminogen activator 3.4.21.73 0.683
4fui UI3Urokinase-type plasminogen activator 3.4.21.73 0.674
2zp0 PI0Coagulation factor VII 3.4.21.21 0.671
1d4p BPPProthrombin 3.4.21.5 0.665
1riw OSCProthrombin 3.4.21.5 0.662
2zhq 27UProthrombin 3.4.21.5 0.662
2zfr 46UProthrombin 3.4.21.5 0.660
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.659
1ype UIPProthrombin 3.4.21.5 0.657
1gj5 130Prothrombin 3.4.21.5 0.653