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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1njd UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1njd UMPThymidylate synthase / 0.968
1bp6 UMPThymidylate synthase / 0.908
1tsy UMPThymidylate synthase / 0.871
1tsv UMPThymidylate synthase / 0.862
1bp0 UMPThymidylate synthase / 0.859
1jmh UMPThymidylate synthase / 0.843
1tsx UMPThymidylate synthase / 0.841
2tdm UMPThymidylate synthase / 0.825
1vzb UMPThymidylate synthase / 0.817
1njc DCMThymidylate synthase / 0.803
1nja DCMThymidylate synthase / 0.790
1jmi UMPThymidylate synthase / 0.776
2g89 UMPThymidylate synthase / 0.769
1bpj UMPThymidylate synthase / 0.767
1njb UMPThymidylate synthase / 0.766
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.744
1bid UMPThymidylate synthase / 0.741
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.739
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.736
5by6 UMPThymidylate synthase / 0.733
2g86 UMPThymidylate synthase / 0.723
1vza UMPThymidylate synthase / 0.719
1nje DCMThymidylate synthase / 0.716
2g8d UMPThymidylate synthase / 0.716
2vet UMPThymidylate synthase / 0.715
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.712
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.711
1f28 UMPThymidylate synthase 2.1.1.45 0.710
1ddu DDUThymidylate synthase / 0.709
4ein NOHThymidylate synthase 2.1.1.45 0.706
2g8a UMPThymidylate synthase / 0.704
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.700
1jmf UMPThymidylate synthase / 0.693
4iqq UMPThymidylate synthase / 0.692
4isk UMPThymidylate synthase / 0.689
2fto TMPThymidylate synthase / 0.685
1bdu DURThymidylate synthase / 0.683
4e5o UMPThymidylate synthase 2.1.1.45 0.683
4dq1 UMPThymidylate synthase / 0.678
1jmg UMPThymidylate synthase / 0.677
4irr UMPThymidylate synthase / 0.676
4fox UMPThymidylate synthase ThyA / 0.672
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.669
4nke IPEFarnesyl pyrophosphate synthase 2.5.1.10 0.664
4ph9 IBPProstaglandin G/H synthase 2 1.14.99.1 0.663
3q7d NPXProstaglandin G/H synthase 2 1.14.99.1 0.658
1thy UMPThymidylate synthase / 0.653
2tsr UMPThymidylate synthase 2.1.1.45 0.650
3n8w FLPProstaglandin G/H synthase 1 1.14.99.1 0.650