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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m7a MQU Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1m7a MQUDihydrofolate reductase 1.5.1.3 0.926
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.792
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.737
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.706
3eel 53TUncharacterized protein / 0.680
4h95 06UDihydrofolate reductase 1.5.1.3 0.680
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.677
3eek 53SUncharacterized protein / 0.676
3qly 55VUncharacterized protein / 0.668
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.664
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.662
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.658
3qls 55VDihydrofolate reductase 1.5.1.3 0.658
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.652