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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m78 CLZ Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1m78 CLZDihydrofolate reductase 1.5.1.3 0.892
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.851
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.805
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.767
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.730
3gyf 51PDihydrofolate reductase 1.5.1.3 0.688
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.687
2w3w VG9Dihydrofolate reductase / 0.687
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.683
3bl7 DD1m7GpppX diphosphatase 3.6.1.59 0.681
3k45 51PDihydrofolate reductase 1.5.1.3 0.672
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.667
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.666
3eko PYUHeat shock protein HSP 90-alpha / 0.659
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.653
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.652
3td8 D2RDihydrofolate reductase 1.5.1.3 0.652