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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kzj CB3 Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kzj CB3Thymidylate synthase / 0.914
1drt PCVClavaminate synthase 1 1.14.11.21 0.744
1g6o ADPCag alpha / 0.744
4a8m ATPRNA-directed RNA polymerase 2.7.7.48 0.744
4ig8 DTP2'-5'-oligoadenylate synthase 1 / 0.744
2bbq PFGThymidylate synthase / 0.684
1trg CB3Thymidylate synthase / 0.672
2tsc CB3Thymidylate synthase / 0.668
3vp6 HLDGlutamate decarboxylase 1 4.1.1.15 0.660
4uxj TTPThymidine kinase / 0.660