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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kxp ATP Actin, alpha skeletal muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kxp ATPActin, alpha skeletal muscle / 1.185
2v51 ATPActin, alpha skeletal muscle / 1.110
1wua ATPActin, alpha skeletal muscle / 1.109
4b1v ATPActin, alpha skeletal muscle / 1.100
1qz5 ATPActin, alpha skeletal muscle / 1.067
3a5o ATPMajor actin / 1.055
4k41 ATPActin, alpha skeletal muscle / 1.054
1nlv ATPMajor actin / 1.030
2a41 ATPActin, alpha skeletal muscle / 1.025
2q36 ATPActin, alpha skeletal muscle / 1.023
3daw ATPActin, alpha skeletal muscle / 1.020
1t44 ATPActin, alpha skeletal muscle / 1.019
4pl8 ATPActin, alpha skeletal muscle / 1.019
3m6g ATPActin, alpha skeletal muscle / 1.018
4pkg ATPActin, alpha skeletal muscle / 1.017
3eks ATPActin-5C / 1.013
3w3d ATPActin, gamma-enteric smooth muscle / 1.008
4pki ATPActin, alpha skeletal muscle / 1.007
1s22 ATPActin, alpha skeletal muscle / 1.001
1eqy ATPActin, alpha skeletal muscle / 1.000
1atn ATPActin, alpha skeletal muscle / 0.998
1c0f ATPMajor actin / 0.992
1dej ATPMajor actin / 0.990
3chw ATPMajor actin / 0.981
3mn6 ATPActin-5C / 0.980
3mn9 ATPActin-5C / 0.977
5ce3 ATPActin / 0.973
3m1f ATPActin, alpha skeletal muscle / 0.971
3eku ATPActin-5C / 0.969
1ijj ATPActin, alpha skeletal muscle / 0.954
3tu5 ATPActin, alpha skeletal muscle / 0.931
2q97 ATPActin, alpha skeletal muscle / 0.924
4cbx ATPActin-2 / 0.923
4pkh ADPActin, alpha skeletal muscle / 0.917
1lot ATPActin, alpha skeletal muscle / 0.909
1mdu ATPActin, alpha skeletal muscle / 0.895
3mn7 ATPActin-5C / 0.894
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.889
2p9k ATPActin-related protein 2 / 0.888
4m63 ATPActin-5C / 0.875
3a5m ATPMajor actin / 0.871
3ffk ATPActin, alpha skeletal muscle / 0.866
1nm1 ATPMajor actin / 0.861
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.860
3d2e ATPHeat shock protein homolog SSE1 / 0.851
3el2 ATPActin-5C / 0.845
1rgi ATPActin, alpha skeletal muscle / 0.840
2oan ATPActin, cytoplasmic 1 / 0.839
4k42 ADPActin, alpha skeletal muscle / 0.836
4a62 ANPPlasmid segregation protein ParM / 0.822
4ci6 ATPActin / 0.799
1rfq ATPActin, alpha skeletal muscle / 0.793
4jhd ANPActin-5C / 0.786
3wt0 ATPCell division protein FtsA / 0.782
1nmd ATPMajor actin / 0.769
2e2q ADPATP-dependent hexokinase / 0.769
1yxq ATPActin, alpha skeletal muscle / 0.760
4k43 ADPActin, alpha skeletal muscle / 0.759
2zgy GDPPlasmid segregation protein ParM / 0.745
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.745
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.745
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.744
3ule ATPActin-related protein 2 / 0.739
2d0o ADPDiol dehydratase-reactivating factor alpha subunit / 0.736
1h1v ATPActin, alpha skeletal muscle / 0.733
2qwl ADPHeat shock cognate 71 kDa protein / 0.720
3wqu ATPCell division protein FtsA / 0.707
4a61 ANPPlasmid segregation protein ParM / 0.704
2zgz GNPPlasmid segregation protein ParM / 0.701
4bqz GNPEctonucleoside triphosphate diphosphohydrolase 2 / 0.701
4a2b AGSCell division protein FtsA / 0.694
5i4n ATPTyrosine-protein kinase JAK2 / 0.685
1mwm ADPPlasmid segregation protein ParM / 0.681
1ngj ANPHeat shock cognate 71 kDa protein / 0.680
4iij GTPTubulin alpha-1B chain / 0.679
3orl AGSSerine/threonine protein kinase / 0.677
4dwb 0M7Farnesyl pyrophosphate synthase / 0.677
1zbd GTPRas-related protein Rab-3A / 0.676
4g5q GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.676
3u4l ATPActin, cytoplasmic 1 / 0.674
2qwq ADPHeat shock cognate 71 kDa protein / 0.673
1nly AGSCag alpha / 0.671
5f1x ATP78 kDa glucose-regulated protein / 0.670
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.669
2x60 GTPMannose-1-phosphate guanylyltransferase / 0.669
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.668
3ldl ATP78 kDa glucose-regulated protein / 0.665
3ryh GTPTubulin alpha chain / 0.664
4m0l GDPTranslation initiation factor 2 subunit gamma / 0.663
1e4g ATPCell division protein FtsA / 0.662
3bxz ADPProtein translocase subunit SecA / 0.662
1nge ATPHeat shock cognate 71 kDa protein / 0.660
1xs4 DCPdCTP deaminase / 0.656
3fcc ATPD-alanine--poly(phosphoribitol) ligase subunit 1 / 0.656
4ymv ATPABC-type polar amino acid transport system, ATPase component / 0.653
2q16 ITTdITP/XTP pyrophosphatase / 0.652
3u5y SCGRaucaffricine-O-beta-D-glucosidase 3.2.1.125 0.651
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
5cpm FNRNADH:flavin oxidoreductase / 0.651
1sxj AGSReplication factor C subunit 1 / 0.650
2fsn ADPArchaeal actin homolog / 0.650