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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kv1 BMU Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kv1 BMUMitogen-activated protein kinase 14 / 1.074
3o8t BMUMitogen-activated protein kinase 14 / 0.879
3oc1 BMUMitogen-activated protein kinase 14 / 0.840
3o8u BMUMitogen-activated protein kinase 14 / 0.833
3p79 P79Mitogen-activated protein kinase 14 / 0.832
3o8p BMUMitogen-activated protein kinase 14 / 0.786
3p78 P78Mitogen-activated protein kinase 14 / 0.777
3nnx EDDMitogen-activated protein kinase 14 / 0.763
3uvr 06FMitogen-activated protein kinase 14 / 0.750
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2puu G2GMitogen-activated protein kinase 14 / 0.743
1wbv LI3Mitogen-activated protein kinase 14 / 0.742
3p7b P7BMitogen-activated protein kinase 14 / 0.740
3p7c P7CMitogen-activated protein kinase 14 / 0.732
3hv3 R49Mitogen-activated protein kinase 14 / 0.723
1w82 L10Mitogen-activated protein kinase 14 / 0.721
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.711
3p5k P5KMitogen-activated protein kinase 14 / 0.711
3p7a P7AMitogen-activated protein kinase 14 / 0.704
3gcu R48Mitogen-activated protein kinase 14 / 0.695
3hv4 L51Mitogen-activated protein kinase 14 / 0.694
3d83 GK6Mitogen-activated protein kinase 14 / 0.693
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.690
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.690
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.684
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.683
3iw8 HIZMitogen-activated protein kinase 14 / 0.682
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.682
3gi3 B10Mitogen-activated protein kinase 14 / 0.681
3lfb Z87Mitogen-activated protein kinase 14 / 0.681
3e93 19BMitogen-activated protein kinase 14 / 0.680
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.679
1w83 L11Mitogen-activated protein kinase 14 / 0.677
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.675
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.673
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.672
3gcq 1BUMitogen-activated protein kinase 14 / 0.668
3bv2 P38Mitogen-activated protein kinase 14 / 0.665
3hv5 R24Mitogen-activated protein kinase 14 / 0.665
3nnu EDBMitogen-activated protein kinase 14 / 0.662
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1kv2 B96Mitogen-activated protein kinase 14 / 0.658
2yis YISMitogen-activated protein kinase 14 / 0.656
3hv6 R39Mitogen-activated protein kinase 14 / 0.653
3k3j F4CMitogen-activated protein kinase 14 / 0.653
4aa0 AA0Mitogen-activated protein kinase 14 / 0.653
3ugc 046Tyrosine-protein kinase JAK2 / 0.652