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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ke9 LS5 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.942
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.874
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.872
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.859
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.858
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.841
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.836
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.836
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.830
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.806
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.801
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.797
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.781
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.779
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.758
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.754
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.745
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.743
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.706
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.700
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.693
3eb0 DRKUncharacterized protein / 0.693
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.688
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.686
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.672
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.669
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.663
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.662
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.660
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.660
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.654
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.653
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.652
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.652
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.651
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.650