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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kce CB3 Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kce CB3Thymidylate synthase / 0.932
2bbq PFGThymidylate synthase / 0.897
1trg CB3Thymidylate synthase / 0.859
2tsc CB3Thymidylate synthase / 0.829
2aaz CB3Thymidylate synthase 2.1.1.45 0.817
1zpr CB3Thymidylate synthase / 0.805
4knz CB3Thymidylate synthase / 0.802
4gev CB3Thymidylate synthase / 0.795
1aiq CB3Thymidylate synthase / 0.786
2fto CB3Thymidylate synthase / 0.779
1dna CB3Thymidylate synthase / 0.768
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3bgx MEFThymidylate synthase / 0.743
1tdu CB3Thymidylate synthase / 0.740
1tys DHFThymidylate synthase / 0.737
2kce D16Thymidylate synthase / 0.735
4eil CB3Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.726
1nce CB3Thymidylate synthase / 0.710
1an5 CB3Thymidylate synthase / 0.699
1bq1 CB3Thymidylate synthase / 0.694
3bhr THGThymidylate synthase / 0.677
4e5f 0N7Polymerase acidic protein / 0.660
1jtq LY3Thymidylate synthase / 0.654