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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jmi UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jmi UMPThymidylate synthase / 0.889
1bp0 UMPThymidylate synthase / 0.813
1tsy UMPThymidylate synthase / 0.798
1vzb UMPThymidylate synthase / 0.792
1nja DCMThymidylate synthase / 0.781
1njd UMPThymidylate synthase / 0.776
1njb UMPThymidylate synthase / 0.752
2tdm UMPThymidylate synthase / 0.749
1bp6 UMPThymidylate synthase / 0.742
1bpj UMPThymidylate synthase / 0.741
1jmh UMPThymidylate synthase / 0.739
1tsx UMPThymidylate synthase / 0.736
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.732
1njc DCMThymidylate synthase / 0.732
4eb4 UMPThymidylate synthase 2.1.1.45 0.729
1nje DCMThymidylate synthase / 0.727
1bid UMPThymidylate synthase / 0.724
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.716
1vza UMPThymidylate synthase / 0.712
1jmf UMPThymidylate synthase / 0.707
2g89 UMPThymidylate synthase / 0.702
1f28 UMPThymidylate synthase 2.1.1.45 0.693
3bgx TMPThymidylate synthase / 0.693
2vet UMPThymidylate synthase / 0.687
5by6 UMPThymidylate synthase / 0.687
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.686
1ddu DDUThymidylate synthase / 0.685
4psg NOHThymidylate synthase / 0.680
1tsv UMPThymidylate synthase / 0.676
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.672
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.671
4dq1 UMPThymidylate synthase / 0.671
1tdc UMPThymidylate synthase / 0.670
4h0u UMPThymidylate synthase / 0.668
2fto TMPThymidylate synthase / 0.667
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.663
2g86 UMPThymidylate synthase / 0.663
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.657
1jmg UMPThymidylate synthase / 0.653
4ein NOHThymidylate synthase 2.1.1.45 0.653
4isk UMPThymidylate synthase / 0.653