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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jmh UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jmh UMPThymidylate synthase / 0.889
1njd UMPThymidylate synthase / 0.843
1bp0 UMPThymidylate synthase / 0.809
1bp6 UMPThymidylate synthase / 0.802
1tsy UMPThymidylate synthase / 0.782
1vzb UMPThymidylate synthase / 0.778
1bid UMPThymidylate synthase / 0.761
1tsv UMPThymidylate synthase / 0.761
1njc DCMThymidylate synthase / 0.758
2tdm UMPThymidylate synthase / 0.753
1bpj UMPThymidylate synthase / 0.746
1nje DCMThymidylate synthase / 0.743
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.741
1nja DCMThymidylate synthase / 0.741
1jmi UMPThymidylate synthase / 0.739
1njb UMPThymidylate synthase / 0.736
2g89 UMPThymidylate synthase / 0.720
1tsx UMPThymidylate synthase / 0.718
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.718
2g8a UMPThymidylate synthase / 0.706
1f28 UMPThymidylate synthase 2.1.1.45 0.705
4e5o UMPThymidylate synthase 2.1.1.45 0.705
2g86 UMPThymidylate synthase / 0.700
4psg NOHThymidylate synthase / 0.692
4eb4 UMPThymidylate synthase 2.1.1.45 0.687
1jmf UMPThymidylate synthase / 0.685
1vza UMPThymidylate synthase / 0.682
1jmg UMPThymidylate synthase / 0.681
5by6 UMPThymidylate synthase / 0.681
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.678
3qj7 UMPThymidylate synthase ThyA / 0.673
1bdu DURThymidylate synthase / 0.672
1ddu DDUThymidylate synthase / 0.670
4isk UMPThymidylate synthase / 0.670
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.668
2vet UMPThymidylate synthase / 0.667
4ein NOHThymidylate synthase 2.1.1.45 0.666
4fox UMPThymidylate synthase ThyA / 0.666
4h0u UMPThymidylate synthase / 0.660
4iqq UMPThymidylate synthase / 0.659
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.656
1thy UMPThymidylate synthase / 0.656
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.655
4dq1 UMPThymidylate synthase / 0.654