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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1izh Q50 Protease

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1izh Q50Protease / 1.399
1izi Q50Gag-Pol polyprotein 3.4.23.16 1.055
1ffi 2NCGag-Pol polyprotein 3.4.23.16 0.974
3dcr KVSProtease / 0.946
2avm 2NCGag-Pol polyprotein 3.4.23.16 0.939
3eky DR7Gag-Pol polyprotein 3.4.23.16 0.925
1fg6 2NCGag-Pol polyprotein 3.4.23.16 0.899
1fgc 2NCGag-Pol polyprotein 3.4.23.16 0.899
1tcx IM1Gag-Pol polyprotein 3.4.23.16 0.898
3dck KVIProtease / 0.895
3nwx KVSGag-Pol polyprotein 3.4.23.16 0.895
3oxx DR7Gag-Pol polyprotein 3.4.23.16 0.886
3em4 DR7Gag-Pol polyprotein 3.4.23.16 0.881
1fg8 0Q4Gag-Pol polyprotein 3.4.23.16 0.868
1iiq 0ZRGag-Pol polyprotein 3.4.23.16 0.867
3i2l 2NCProtease / 0.857
1fej 2NCGag-Pol polyprotein 3.4.23.16 0.849
1k2b 0Q4Gag-Pol polyprotein 3.4.23.16 0.845
2aqu DR7Gag-Pol polyprotein 3.4.23.16 0.844
1ff0 2NCGag-Pol polyprotein 3.4.23.16 0.840
2qi5 MZ7Gag-Pol polyprotein / 0.839
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.832
1k1u 0Q4Gag-Pol polyprotein 3.4.23.16 0.830
1ec1 BEEGag-Pol polyprotein 3.4.23.16 0.828
1daz 0Q4Gag-Pol polyprotein 3.4.23.16 0.827
1zsr 0ZTGag-Pol polyprotein 3.4.23.16 0.825
3kf0 3TLGag-Pol polyprotein / 0.823
1k2c 0Q4Gag-Pol polyprotein 3.4.23.16 0.822
2q54 MU1Protease / 0.820
3sab F78Protease / 0.820
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.819
2f80 017Gag-Pol polyprotein 3.4.23.16 0.818
1ebz BECGag-Pol polyprotein 3.4.23.16 0.812
3ekw DR7Gag-Pol polyprotein 3.4.23.16 0.812
1m0b 0ZQGag-Pol polyprotein 3.4.23.16 0.811
3pwm 017Gag-Pol polyprotein 3.4.23.16 0.810
2cem 2AHPol protein / 0.807
2qak 1UNGag-Pol polyprotein 3.4.23.16 0.807
3o9a K14Pol polyprotein / 0.807
2p3b 3TLV-1 PROTEASE protein / 0.805
2p3b 3TLV-1 protease / 0.805
1siv PSIGag-Pol polyprotein / 0.804
2wkz 5AHGag-Pol polyprotein / 0.801
1ec2 BEJGag-Pol polyprotein 3.4.23.16 0.799
3o9h K2EGag-Pol polyprotein / 0.794
3o9b K2APol polyprotein / 0.793
3o9i A61Gag-Pol polyprotein / 0.787
1dw6 0Q4Gag-Pol polyprotein 3.4.23.16 0.785
3vfa 031Gag-Pol polyprotein 3.4.23.16 0.784
2aoe 0Q4Gag-Pol polyprotein 3.4.23.16 0.782
2qi0 MZ3Gag-Pol polyprotein / 0.782
3mws 017Pol protein / 0.782
1fff 0Q4Gag-Pol polyprotein 3.4.23.16 0.781
1npv L27Gag-Pol polyprotein 3.4.23.16 0.781
1zj7 0ZTGag-Pol polyprotein 3.4.23.16 0.781
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.779
3gga GGWGag-Pol polyprotein / 0.779
3o9f K2DGag-Pol polyprotein / 0.778
3o9g F53Gag-Pol polyprotein / 0.778
3ndx RITGag-Pol polyprotein 3.4.23.16 0.776
1ec3 MS3Gag-Pol polyprotein 3.4.23.16 0.775
3kfr 3TLGag-Pol polyprotein / 0.773
3o9e A60Pol polyprotein / 0.773
2a1e IPFGag-Pol polyprotein 3.4.23.16 0.771
4k4p 3TLGag-Pol polyprotein / 0.770
1z1h HBBGag-Pol polyprotein 3.4.23.16 0.769
3o9d K19Pol polyprotein / 0.769
3sa9 A68Protease / 0.769
3s85 LK0Gag-Pol polyprotein / 0.768
4kb9 G79Protease / 0.767
1bdq IM1Gag-Pol polyprotein 3.4.23.16 0.766
4q1w 017Gag-Pol polyprotein 3.4.23.16 0.766
4njs G08Protease / 0.764
2bpx MK1Gag-Pol polyprotein 3.4.23.16 0.762
2qhy MZ1Gag-Pol polyprotein / 0.761
4hdp G52Gag-Pol polyprotein 3.4.23.16 0.761
4dqf 017Gag-Pol polyprotein / 0.760
1w5v BE3Gag-Pol polyprotein 3.4.23.16 0.759
3st5 G89Gag-Pol polyprotein 3.4.23.16 0.759
4heg G52Gag-Pol polyprotein 3.4.23.16 0.758
1ody LP1Gag-Pol polyprotein 3.4.23.16 0.756
2q63 1UNGag-Pol polyprotein 3.4.23.16 0.756
1ida 0POGag-Pol polyprotein 3.4.23.47 0.755
2qci 065Gag-Pol polyprotein 3.4.23.16 0.755
3oy4 017Gag-Pol polyprotein 3.4.23.16 0.755
3fx5 KNIGag-Pol polyprotein 3.4.23.16 0.753
1eby BEBGag-Pol polyprotein 3.4.23.16 0.752
2qd8 065Gag-Pol polyprotein 3.4.23.16 0.751
3em3 478Gag-Pol polyprotein 3.4.23.16 0.751
4dqe 017Gag-Pol polyprotein / 0.751
1msn JE2Gag-Pol polyprotein 3.4.23.16 0.750
3lzv 017Gag-Pol polyprotein 3.4.23.16 0.750
3ndu ROCGag-Pol polyprotein 3.4.23.16 0.750
3r4b 74TGag-Pol polyprotein / 0.750
1hvk A79Gag-Pol polyprotein / 0.749
1g35 AHFGag-Pol polyprotein 3.4.23.16 0.748
3bxr DRRGag-Pol polyprotein 3.4.23.16 0.748
3ndw RITGag-Pol polyprotein 3.4.23.16 0.748
1d4i BEGGag-Pol polyprotein 3.4.23.16 0.747
2f3k RO1Protease / 0.747
1d4h BEHGag-Pol polyprotein 3.4.23.16 0.746
1sdv MK1Gag-Pol polyprotein 3.4.23.16 0.746
2z4o 065Gag-Pol polyprotein 3.4.23.16 0.746
3qaa G04Gag-Pol polyprotein 3.4.23.16 0.746
4dfg 0JVGag-Pol polyprotein 3.4.23.16 0.746
3bva 2NCGag-Pol polyprotein 3.4.23.16 0.745
2hb3 GRLProtease / 0.744
1ohr 1UNV-1 PROTEASE protein / 0.742
1t3r 017Gag-Pol polyprotein 3.4.23.16 0.742
2f81 017Gag-Pol polyprotein 3.4.23.16 0.742
3nwq 2NCGag-Pol polyprotein 3.4.23.16 0.742
1mrw K57Gag-Pol polyprotein 3.4.23.16 0.740
3jw2 017Gag-Pol polyprotein 3.4.23.16 0.739
3o9c K20Pol polyprotein / 0.739
3zps EQMGag-Pol polyprotein 3.4.23.16 0.739
1hos PHPGag-Pol polyprotein / 0.738
2bb9 AKCGag-Pol polyprotein 3.4.23.16 0.738
3o99 K13Pol polyprotein / 0.738
3tof 076Gag-Pol polyprotein 2.7.7.49 0.738
1z1r HBHGag-Pol polyprotein 3.4.23.16 0.736
3nu6 478Gag-Pol polyprotein 3.4.23.16 0.736
4dqh 017Gag-Pol polyprotein / 0.736
3ekv 478Gag-Pol polyprotein 3.4.23.16 0.734
3nu4 478Gag-Pol polyprotein 3.4.23.16 0.734
1a8g 2Z4Gag-Pol polyprotein 3.4.23.16 0.733
3sa5 A69Protease / 0.732
1bdr IM1Gag-Pol polyprotein 3.4.23.16 0.731
1hih C20Gag-Pol polyprotein / 0.731
3kfs 3TLGag-Pol polyprotein / 0.730
3nxe 2NCProtease / 0.729
3sa7 55AProtease / 0.729
3sa8 K83Protease / 0.728
2cen 4AHProtease / 0.727
4q1y 017Gag-Pol polyprotein 3.4.23.16 0.727
2bbb HH1Gag-Pol polyprotein 3.4.23.16 0.726
3ec0 GRLGag-Pol polyprotein 3.4.23.47 0.726
1a8k 0Q4Gag-Pol polyprotein 3.4.23.16 0.725
1hiv 1ZKGag-Pol polyprotein / 0.725
1w5w BE4Gag-Pol polyprotein 3.4.23.16 0.724
3em6 017Gag-Pol polyprotein 3.4.23.16 0.724
3oxv 478Gag-Pol polyprotein 3.4.23.16 0.723
1hvs A77Gag-Pol polyprotein / 0.722
2i4u DJRProtease / 0.722
4hdb G52Gag-Pol polyprotein 3.4.23.16 0.722
1hpx KNIGag-Pol polyprotein / 0.721
3kfn 3TLGag-Pol polyprotein / 0.721
4i8z G08Gag-Pol polyprotein 3.4.23.16 0.721
2qhc AB1Protease / 0.720
3oxw 017Gag-Pol polyprotein 3.4.23.16 0.720
1a94 0Q4Gag-Pol polyprotein 3.4.23.16 0.719
2pk5 075Protease / 0.719
3i6o GR6Gag-Pol polyprotein 3.4.23.16 0.719
4njv RITProtease / 0.719
3saa 77FProtease / 0.718
2pym 1UNGag-Pol polyprotein 3.4.23.16 0.717
3nu9 478Gag-Pol polyprotein 3.4.23.16 0.716
3t3c 017Gag-Pol polyprotein 3.4.23.16 0.716
3toh 079Gag-Pol polyprotein 2.7.7.49 0.716
4ye3 G04Gag-Pol polyprotein 3.4.23.16 0.716
2i4w KGQProtease / 0.714
2rkf AB1Pol protein / 0.714
2p3c 3TLProtease / 0.713
3kdb 006Gag-Pol polyprotein 3.4.23.16 0.713
2xyf G40Gag-Pol polyprotein / 0.712
3sa3 23XProtease / 0.712
1mtr PI6Gag-Pol polyprotein 3.4.23.16 0.711
2fxd DR7Pol polyprotein / 0.711
3zpu M8BGag-Pol polyprotein 3.4.23.16 0.711
1hsh MK1Gag-Pol polyprotein / 0.710
1a9m U0EGag-Pol polyprotein / 0.709
1msm JE2Gag-Pol polyprotein 3.4.23.16 0.709
2hs1 017Protease / 0.708
3nuo 478Gag-Pol polyprotein 3.4.23.16 0.708
3sa4 F72Protease / 0.708
2fdd 385Pol protein / 0.707
3vfb 031Gag-Pol polyprotein 3.4.23.16 0.707
3zpt M8YGag-Pol polyprotein 3.4.23.16 0.707
1k6c MK1Gag-Pol polyprotein 3.4.23.16 0.706
2psv MUVProtease / 0.706
3nls 016Gag-Pol polyprotein 3.4.23.16 0.706
4dqc 017Gag-Pol polyprotein / 0.706
1hsg MK1Gag-Pol polyprotein / 0.705
1sdt MK1Gag-Pol polyprotein 3.4.23.16 0.705
2psu MUUProtease / 0.705
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.704
3ucb 017Gag-Pol polyprotein / 0.704
1sbg IM1Gag-Pol polyprotein / 0.703
1t7i 017Gag-Pol polyprotein 3.4.23.16 0.703
4djp M73Pol polyprotein / 0.703
4dqb 017Gag-Pol polyprotein / 0.702
2p3a 3TLPol protein / 0.700
2pyn 1UNGag-Pol polyprotein 3.4.23.16 0.700
2qd7 065Gag-Pol polyprotein 3.4.23.16 0.700
2wl0 5AHGag-Pol polyprotein / 0.700
2hs2 017Protease / 0.699
4hla 017Gag-Pol polyprotein 3.4.23.16 0.698
1odx 0E8Gag-Pol polyprotein 3.4.23.16 0.696
2qnp QN2Gag-Pol polyprotein 3.4.23.16 0.696
1npa 3NHGag-Pol polyprotein 3.4.23.16 0.694
1npw LGZGag-Pol polyprotein 3.4.23.16 0.694
2fle AIProtease / 0.694
1g2k NM1Gag-Pol polyprotein 3.4.23.16 0.693
2qi6 MZ8Gag-Pol polyprotein / 0.693
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.692
2f8g 017Gag-Pol polyprotein 3.4.23.16 0.692
2xye CXGGag-Pol polyprotein / 0.692
3d1z 017Gag-Pol polyprotein 3.4.23.16 0.692
3ekt 017Gag-Pol polyprotein 3.4.23.16 0.692
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.692
1w5y BE6Gag-Pol polyprotein 3.4.23.16 0.691
3s54 017Protease / 0.691
3nu3 478Gag-Pol polyprotein 3.4.23.16 0.689
2q64 1UNGag-Pol polyprotein 3.4.23.16 0.688
3ggu 017Gag-Pol polyprotein 3.4.23.16 0.688
3nyg 2NCGag-Pol polyprotein 3.4.23.16 0.688
1d4k PI8Gag-Pol polyprotein 3.4.23.16 0.687
1hxw RITGag-Pol polyprotein / 0.687
2ien 017Gag-Pol polyprotein 3.4.23.16 0.685
4j55 031Gag-Pol polyprotein 3.4.23.16 0.685
3nu5 478Gag-Pol polyprotein 3.4.23.16 0.684
1dif A85Gag-Pol polyprotein / 0.683
1mui AB1Protease / 0.683
1odw 0E8Gag-Pol polyprotein 3.4.23.16 0.683
4rvj 478Protease / 0.683
2bqv A1AProtease / 0.682
2fde 385Gag-Pol polyprotein 3.4.23.16 0.682
3tog 079Gag-Pol polyprotein 2.7.7.49 0.682
4q1x 017Gag-Pol polyprotein 3.4.23.16 0.682
3hzc 2NCProtease / 0.681
3mxe K54Gag-Pol polyprotein 3.4.23.16 0.681
1d4l PI9Gag-Pol polyprotein 3.4.23.16 0.680
2r3t G4GGag-Pol polyprotein 3.4.23.16 0.680
2qi4 MZ6Gag-Pol polyprotein / 0.679
3s56 ROCProtease / 0.679
2pqz G0GGag-Pol polyprotein 3.4.23.16 0.678
2q5k AB1Protease / 0.678
3ecg 065Gag-Pol polyprotein 3.4.23.47 0.678
4hdf G52Gag-Pol polyprotein 3.4.23.16 0.677
1k6v XN2Gag-Pol polyprotein 3.4.23.16 0.676
3slz 3TLPutative gag-pro-pol polyprotein / 0.676
3s43 478Protease / 0.674
3sm2 478Putative gag-pro-pol polyprotein / 0.674
4j54 G52Gag-Pol polyprotein 3.4.23.16 0.674
4j5j 478Gag-Pol polyprotein 3.4.23.16 0.671
1fb7 ROCGag-Pol polyprotein / 0.669
2qd6 065Gag-Pol polyprotein 3.4.23.16 0.669
3jvw DMPGag-Pol polyprotein 3.4.23.16 0.669
1rl8 RITGag-Pol polyprotein 3.4.23.16 0.668
2nnp ROCProtease / 0.668
3nuj 478Gag-Pol polyprotein 3.4.23.16 0.668
1c6z ROCProtease / 0.667
1hvr XK2Gag-Pol polyprotein / 0.666
2bpz 3INGag-Pol polyprotein 3.4.23.16 0.666
2qnn QN1Gag-Pol polyprotein 3.4.23.16 0.666
3el4 ROCGag-Pol polyprotein 3.4.23.16 0.666
4njt 017Protease / 0.665
1vik BAYGag-Pol polyprotein / 0.664
3ggx GGXGag-Pol polyprotein / 0.664
1hvj A78Gag-Pol polyprotein / 0.663
2i0a MUIProtease / 0.663
1ajv NMBGag-Pol polyprotein 3.4.23.16 0.661
1wbm BLLPol protein / 0.661
3el0 1UNGag-Pol polyprotein 3.4.23.16 0.661
4a4q UX9Pol protein / 0.660
1d4j MSCGag-Pol polyprotein 3.4.23.16 0.659
4djo MK5Pol polyprotein / 0.659
2a4f AAUV-1 protease / 0.658
1dmp DMQGag-Pol polyprotein 3.4.23.16 0.657
1k6p XN3Gag-Pol polyprotein 3.4.23.16 0.657
3d1y ROCGag-Pol polyprotein 3.4.23.16 0.657
1b6l PI4Gag-Pol polyprotein 3.4.23.16 0.656
1ebk 0Q4Gag-Pol polyprotein 3.4.23.16 0.656
1n49 RITGag-Pol polyprotein 3.4.23.16 0.656
3d20 017Gag-Pol polyprotein 3.4.23.16 0.656
1bai 0Q4Gag-Pro polyprotein / 0.655
3ttp 017Gag-Pol polyprotein 3.4.23.16 0.655
2nnk ROCProtease / 0.654
3jvy 017Gag-Pol polyprotein 3.4.23.16 0.654
1ebw BEIGag-Pol polyprotein 3.4.23.16 0.653
1mer DMQGag-Pol polyprotein 3.4.23.16 0.653
2qi7 MZ9Gag-Pol polyprotein / 0.652
2z54 AB1Gag-Pol polyprotein 3.4.23.16 0.652
3bgb LJGGag-Pol polyprotein 3.4.23.16 0.652
3qro NK9Gag-Pol polyprotein 3.4.23.16 0.652
1hii C20Gag-Pol polyprotein / 0.651
3vf7 031Gag-Pol polyprotein 3.4.23.16 0.651
2bpy 3INGag-Pol polyprotein 3.4.23.16 0.650