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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1iei ZES Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1iei ZESAldose reductase 1.1.1.21 1.061
1us0 LDTAldose reductase 1.1.1.21 0.813
3ld5 LDTAldose reductase 1.1.1.21 0.809
2i17 LDTAldose reductase 1.1.1.21 0.803
2i16 LDTAldose reductase 1.1.1.21 0.802
2qxw LDTAldose reductase 1.1.1.21 0.802
3lz5 LDTAldose reductase 1.1.1.21 0.796
3m4h 388Aldose reductase 1.1.1.21 0.795
3lbo LDTAldose reductase 1.1.1.21 0.784
3ghu LDTAldose reductase 1.1.1.21 0.779
3ght LDTAldose reductase 1.1.1.21 0.770
3lql LDTAldose reductase 1.1.1.21 0.762
2iki 388Aldose reductase 1.1.1.21 0.744
4gca 2X9Aldose reductase 1.1.1.21 0.743
1pwl BFIAldose reductase 1.1.1.21 0.738
1z3n 3NAAldose reductase 1.1.1.21 0.716
3ghr LDTAldose reductase 1.1.1.21 0.716
3ghs LDTAldose reductase 1.1.1.21 0.716
3g5e Q74Aldose reductase 1.1.1.21 0.715
2ikj 393Aldose reductase 1.1.1.21 0.714
3t42 3T4Aldose reductase 1.1.1.21 0.698
3mc5 393Aldose reductase 1.1.1.21 0.693
2pdj 393Aldose reductase 1.1.1.21 0.684
2pdu 393Aldose reductase 1.1.1.21 0.683
2fz9 ZSTAldose reductase 1.1.1.21 0.679
3m64 393Aldose reductase 1.1.1.21 0.676
2pdx ZSTAldose reductase 1.1.1.21 0.674
3m0i ZSTAldose reductase 1.1.1.21 0.673
2pzn 393Aldose reductase 1.1.1.21 0.662
2is7 2CLAldose reductase 1.1.1.21 0.653