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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ics FMN 12-oxophytodienoate reductase 1 1.3.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 1.230
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.198
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.183
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.166
3p62 FMNPentaerythritol tetranitrate reductase / 1.054
1vyr FMNPentaerythritol tetranitrate reductase / 1.047
3p74 FMNPentaerythritol tetranitrate reductase / 1.038
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.033
4awt FMNNADH:flavin oxidoreductase Sye1 / 1.031
3p84 FMNPentaerythritol tetranitrate reductase / 1.020
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.019
3p8i FMNPentaerythritol tetranitrate reductase / 1.015
1h50 FMNPentaerythritol tetranitrate reductase / 1.014
1h63 FMNPentaerythritol tetranitrate reductase / 1.014
1h51 FMNPentaerythritol tetranitrate reductase / 1.013
3p67 FMNPentaerythritol tetranitrate reductase / 1.013
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 1.010
4aws FMNNADH:flavin oxidoreductase Sye1 / 1.010
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.008
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 1.005
3f03 FMNPentaerythritol tetranitrate reductase / 1.003
4jic FMNGTN Reductase / 0.999
1gwj FMNMorphinone reductase / 0.997
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.995
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.994
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.993
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.992
3p8j FMNPentaerythritol tetranitrate reductase / 0.989
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.988
4tmb FMNOld yellow enzyme / 0.978
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.975
3p82 FMNPentaerythritol tetranitrate reductase / 0.969
3aty FMNProstaglandin F2a synthase / 0.968
4tmc FMNOld yellow enzyme / 0.963
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.957
5cpm FNRNADH:flavin oxidoreductase / 0.952
2h8x FMNXenA / 0.950
4utm FNRXenobiotic reductase / 0.949
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.948
4utl FNRXenobiotic reductase / 0.945
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.944
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.944
3l67 FMNXenobiotic reductase / 0.941
4e2b FMNDehydrogenase / 0.936
3atz FMNProstaglandin F2a synthase / 0.935
4e2d FMNDehydrogenase / 0.934
4df2 FMNNADPH dehydrogenase / 0.925
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.924
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.924
3gka FMNN-ethylmaleimide reductase / 0.921
3tjl FMNNADPH dehydrogenase / 0.921
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.908
3n19 FNRXenobiotic reductase / 0.904
3l5l FMNXenobiotic reductase / 0.902
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.894
3n14 FMNXenobiotic reductase / 0.893
4uth FMNXenobiotic reductase / 0.887
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.883
1z44 FMNNADPH dehydrogenase / 0.862
1z48 FMNNADPH dehydrogenase / 0.856
1z41 FMNNADPH dehydrogenase / 0.846
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.845
2zfa FMNLactate oxidase / 0.837
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.836
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.836
2nli FMNLactate oxidase / 0.836
1vhn FMNtRNA-dihydrouridine synthase / 0.832
2abb FMNPentaerythritol tetranitrate reductase / 0.832
4yl2 FMNLactate oxidase / 0.825
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.819
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.815
2j6x FMNLactate oxidase / 0.814
4rje FNRLactate oxidase / 0.803
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.802
4yco FMNtRNA-dihydrouridine(16) synthase / 0.799
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.793
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.791
5ebu FMNLactate oxidase / 0.791
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.787
4qai FMNNADPH dehydrogenase / 0.787
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.780
2du2 FMNLactate oxidase / 0.768
3hf3 FMNChromate reductase / 0.766
2e77 FMNLactate oxidase / 0.762
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.757
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.753
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.750
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.749
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.744
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.743
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.741
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.735
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.729
3gr8 FMNNADPH dehydrogenase / 0.707
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.706
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.705
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.701
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.694
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.694
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.693
4cw5 FMNDfnA / 0.692
2b3d FADModulator of drug activity B / 0.690
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.686
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
3w77 FMNFMN-dependent NADH-azoreductase / 0.684
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.682
4bc7 FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.681
3qe2 FMNNADPH--cytochrome P450 reductase / 0.680
2z9d FMNFMN-dependent NADH-azoreductase / 0.676
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.676
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.675
3qfr FMNNADPH--cytochrome P450 reductase / 0.675
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.675
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.672
2gr3 FADFerredoxin reductase / 0.669
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.667
2q9u FMNA-type flavoprotein / 0.666
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.665
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.664
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.664
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.662
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.661
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.660
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
4hnb FMNLOV protein / 0.659
3in6 FMNUncharacterized protein / 0.658
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.658
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.656
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.653
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.652
2z6c FMNPhototropin-1 2.7.11.1 0.652
3ojw FMNNADPH--cytochrome P450 reductase / 0.652
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.652
4j8p FMNFlavodoxin / 0.652
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.651
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.650
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.650
4fhb FOLDihydrofolate reductase 1.5.1.3 0.650