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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1icp FMN 12-oxophytodienoate reductase 1 1.3.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.287
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 1.198
3p62 FMNPentaerythritol tetranitrate reductase / 1.129
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.111
3p74 FMNPentaerythritol tetranitrate reductase / 1.108
3p82 FMNPentaerythritol tetranitrate reductase / 1.094
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.063
3f03 FMNPentaerythritol tetranitrate reductase / 1.058
3p8i FMNPentaerythritol tetranitrate reductase / 1.057
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 1.048
1h50 FMNPentaerythritol tetranitrate reductase / 1.045
3p67 FMNPentaerythritol tetranitrate reductase / 1.044
1vyr FMNPentaerythritol tetranitrate reductase / 1.040
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 1.033
1h51 FMNPentaerythritol tetranitrate reductase / 1.031
1h63 FMNPentaerythritol tetranitrate reductase / 1.030
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.007
4awt FMNNADH:flavin oxidoreductase Sye1 / 1.005
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 1.004
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 1.000
4jic FMNGTN Reductase / 0.999
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.986
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.985
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.984
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.983
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.970
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.970
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.964
4e2d FMNDehydrogenase / 0.957
4tmb FMNOld yellow enzyme / 0.951
1gwj FMNMorphinone reductase / 0.950
3aty FMNProstaglandin F2a synthase / 0.948
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.943
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.942
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.940
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.939
4e2b FMNDehydrogenase / 0.936
3l67 FMNXenobiotic reductase / 0.931
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.920
3atz FMNProstaglandin F2a synthase / 0.916
2h8x FMNXenA / 0.910
4tmc FMNOld yellow enzyme / 0.910
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.900
5cpm FNRNADH:flavin oxidoreductase / 0.899
4df2 FMNNADPH dehydrogenase / 0.898
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.888
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.884
4utl FNRXenobiotic reductase / 0.883
4m5p FMNNADPH dehydrogenase / 0.880
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.873
3n19 FNRXenobiotic reductase / 0.860
3tjl FMNNADPH dehydrogenase / 0.860
3l5l FMNXenobiotic reductase / 0.849
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.844
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.842
1z48 FMNNADPH dehydrogenase / 0.842
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.841
3gka FMNN-ethylmaleimide reductase / 0.833
1z44 FMNNADPH dehydrogenase / 0.829
3hf3 FMNChromate reductase / 0.829
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.827
4qai FMNNADPH dehydrogenase / 0.822
2zfa FMNLactate oxidase / 0.819
2nli FMNLactate oxidase / 0.814
1vhn FMNtRNA-dihydrouridine synthase / 0.809
1z41 FMNNADPH dehydrogenase / 0.805
3p8j FMNPentaerythritol tetranitrate reductase / 0.804
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.802
3p84 FMNPentaerythritol tetranitrate reductase / 0.800
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.797
4rje FNRLactate oxidase / 0.796
4yl2 FMNLactate oxidase / 0.796
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.793
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.789
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.789
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.788
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.780
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.779
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.774
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.771
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.770
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.769
2e77 FMNLactate oxidase / 0.756
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.755
5ebu FMNLactate oxidase / 0.754
4utm FNRXenobiotic reductase / 0.752
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.750
2abb FMNPentaerythritol tetranitrate reductase / 0.748
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.747
2j6x FMNLactate oxidase / 0.746
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.739
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.736
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.728
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.727
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.721
4z38 FMNMlnA / 0.719
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.715
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.715
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.711
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.695
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.695
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.694
4bc7 FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.687
4cw5 FMNDfnA / 0.686
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.682
2vyx FMNDodecin / 0.679
4utk FNRXenobiotic reductase / 0.679
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.679
4bby FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.677
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.676
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.675
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.675
3w77 FMNFMN-dependent NADH-azoreductase / 0.675
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.675
4j8p FMNFlavodoxin / 0.675
2q9u FMNA-type flavoprotein / 0.674
2pr5 FMNBlue-light photoreceptor / 0.673
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.671
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.669
2gr3 FADFerredoxin reductase / 0.669
2v18 FMNDodecin / 0.669
2z9d FMNFMN-dependent NADH-azoreductase / 0.669
2c3d COM2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.668
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.667
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.665
2gjl FMNNitronate monooxygenase 1.13.12.16 0.664
2hfo FMNActivator of photopigment and puc expression / 0.662
2z6i FMN2-nitropropane dioxygenase / 0.660
1tj1 FADBifunctional protein PutA 1.5.5.2 0.659
2g8d UMPThymidylate synthase / 0.658
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.657
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.657
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.656
3qfr FMNNADPH--cytochrome P450 reductase / 0.656
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.655
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.655
2z6c FMNPhototropin-1 2.7.11.1 0.655
1yrx FMNAppA protein / 0.654
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.654
3bgx TMPThymidylate synthase / 0.654
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.653
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.653
4q4k FMNUncharacterized protein / 0.652
3qe2 FMNNADPH--cytochrome P450 reductase / 0.651
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.651