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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1i44 ACP Insulin receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1i44 ACPInsulin receptor 2.7.10.1 0.974
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.793
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.734
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.709
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.700
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.695
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.690
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.686
2pup ADPMethylthioribose kinase 2.7.1.100 0.686
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.685
2olc ADPMethylthioribose kinase 2.7.1.100 0.683
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4xlv ACPInsulin receptor 2.7.10.1 0.682
4c3r ACPAurora kinase A 2.7.11.1 0.681
4qny ANPMitogen activated protein kinase, putative / 0.680
2pui ADPMethylthioribose kinase 2.7.1.100 0.678
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.676
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.675
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.672
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.670
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.668
2e07 SAHDiphthine synthase / 0.668
2e7r SAHDiphthine synthase / 0.668
2egb SAHDiphthine synthase / 0.668
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
2e15 SAHDiphthine synthase / 0.667
3wnz ADPAlanine--anticapsin ligase / 0.667
2dxw SAHDiphthine synthase / 0.666
2egl SAHDiphthine synthase / 0.666
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.665
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.663
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.662
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.662
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.661
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.661
3q5i ANPProtein kinase, putative / 0.661
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.661
4dt8 ADNAPH(2'')-Id / 0.660
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.658
1u54 ACPActivated CDC42 kinase 1 / 0.658
2pul ACPMethylthioribose kinase 2.7.1.100 0.658
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.658
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.657
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.657
4utd ACPAurora kinase A 2.7.11.1 0.657
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.656
3c4z ADPRhodopsin kinase / 0.656
4n57 ADPAPH(2'')-Id / 0.656
2pun ACPMethylthioribose kinase 2.7.1.100 0.655
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.655
2ehl SAHDiphthine synthase / 0.654
2z6r SAHDiphthine synthase / 0.654
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.653
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2p6i SAHDiphthine synthase / 0.652
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.652
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.652
2eh2 SAHDiphthine synthase / 0.651
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
2ek7 SAHDiphthine synthase / 0.650
2hut SAHDiphthine synthase / 0.650
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.650
4id7 1G0Activated CDC42 kinase 1 / 0.650